Cefuroxime Sulfoxide

Product Information

• Product Code：C022019

• English Name：Cefuroxime Impurity 19

• English Alias：(E)-2-(furan-2-yl)-2-(methoxyimino)acetic acid

• CAS No.：69384-96-9

• Molecular Formula：C?H?NO?

• Molecular Weight：169.13

Advantages

• High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), and HRMS, suitable for precise analysis of Cefuroxime impurities.

• Stability Assurance：Stable for 24 months at 2-8℃ under light-protected, sealed storage; degradation rate <0.3% in methanol solution within 1 month.

Applications

• Quality Control Testing：Used for HPLC and LC-MS detection of Impurity 19 in Cefuroxime API and formulations, controlling impurity content to meet ICH Q3A standards (≤0.1%).

• Process Optimization Research：Monitors impurity formation during Cefuroxime synthesis, reducing generation by >50% by adjusting methoxyimination temperature (e.g., 10-15℃) and reaction time.

• Method Validation：Serves as a standard for developing impurity detection methods, verifying HPLC resolution (≥2.0) and LOD (0.01 ng/mL).

Background Description

Research Status

• Detection Technology：UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 1.8 minutes, with LOD of 0.002 ng/mL for trace analysis.

• Formation Mechanism：Formed by reaction of furanacetic acid with methoxyamine under alkaline conditions (e.g., sodium carbonate catalysis); optimizing reaction pH (8.0-9.0) and reagent ratio inhibits side reactions.

• Safety Evaluation：In vitro antibacterial assays show MIC >64 μg/mL against Staphylococcus aureus (Cefuroxime MIC=0.5 μg/mL), with low toxicity but requiring ≤0.1% limit. Long-term stability testing is ongoing for degradation monitoring.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.

This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!