Cefuroxime Sulfoxide

Product Information

• Product Code：C022021

• English Name：Cefuroxime Sulfoxide

• English Alias：(6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide

• CAS No.：[Not Available]

• Molecular Formula：C??H??N?O?S

• Molecular Weight：440.38

Advantages

• High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and circular dichroism for stereostructure, suitable for precise analysis of Cefuroxime sulfoxide impurities.

• Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.2% in acetonitrile-water solution within 6 months.

Applications

• Quality Control Testing：Used for UPLC-MS/MS detection of sulfoxide impurities in Cefuroxime API and formulations, controlling impurity content to meet ICH Q3A standards (≤0.1%).

• Process Optimization Research：Monitors Cefuroxime Sulfoxide formed by oxidation side reactions during Cefuroxime synthesis or storage, reducing generation by >60% by adjusting reaction temperature (e.g., 5-10℃) and antioxidant dosage.

• Method Validation：Serves as a standard for developing sulfoxide impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description

Research Status

• Detection Technology：UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 3 minutes, with LOD of 0.005 ng/mL for trace analysis.

• Formation Mechanism：Formed by oxidation of the sulfur atom in Cefuroxime molecules under the action of oxygen or peroxides; optimizing antioxidant conditions (e.g., nitrogen protection) and purification processes (e.g., cryogenic crystallization) inhibits its formation.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.

This product is intended for laboratory use only!

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E-mail: anna@molcoo.com

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