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Postion:Product Catalog >Bromhexine Impurity
Bromhexine Impurity
  • Bromhexine Impurity
  • Bromhexine Impurity
  • Bromhexine Impurity
  • Bromhexine Impurity
  • Bromhexine Impurity

Bromhexine Impurity NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-31

Product Details

Product Name: Bromhexine Impurity CAS No.: 740758-41-2
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/31
Molecular formula: C8H10Br2N2

Bromhexine Impurity;740758-41-2

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


  • Product Information

  • Product Number: B008036

  • English Name: Bromhexine Impurity 36

  • English Alias: 2,4-dibromo-6-((methylamino)methyl)aniline

  • CAS Number: 740758-41-2

  • Molecular Formula: C?H??Br?N?

  • Molecular Weight: 293.99

  • Advantages

  • As an impurity reference standard for bromhexine, this compound has the following advantages:

  • Well-defined structure and high stability, which can be used to analyze the by-product formation mechanism of bromination and amination reactions in bromhexine synthesis, optimizing processes to control dibromo impurity generation;

  • As a reference standard containing bromine atoms and amino groups, it provides a standard substance for detecting halogenated aromatic amine impurities in drugs, improving the quantitative accuracy of methods such as HPLC;

  • Helps study the impact of bromine substituents on drug stability and toxicological properties (halogenated aromatic amines may have potential genotoxicity) to provide a scientific basis for impurity control strategies.

  • Applications

  • Drug Development: Used as an impurity reference standard to identify and quantify Impurity 36 in bromhexine preparations, evaluating the purity of APIs and formulations;

  • Quality Control: Acting as a standard substance to validate the sensitivity of detection methods (e.g., HPLC or LC-MS), ensuring the impurity content meets pharmacopoeia requirements during production;

  • Toxicological Research: Assisting in evaluating the potential genotoxicity of halogenated aromatic amine impurities to provide data support for drug safety evaluation.

  • Background Description

  • Bromhexine is a mucolytic drug used for treating respiratory diseases. If the brominating reagent is excessive or the amination reaction conditions are out of control during its synthesis, dibromo impurities such as 2,4-dibromo-6-((methylamino)methyl)aniline are easily generated. Since halogenated aromatic amine compounds may have potential carcinogenic risks, research on this impurity is an important part of bromhexine quality control and safety assessment.
  • Research Status

  • Current research focuses on:

  • Synthesis Methods: Developing high-purity synthesis processes for Impurity 36 to solve the purification challenges of halogenated aromatic amines and meet the needs of toxicological research;

  • Detection Technologies: Establishing trace detection methods (detection limits reach ppb level) for this impurity using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) technology;

  • Toxicological Evaluation: Studying the potential mutagenicity of bromine substituents through in vitro Ames tests and animal models;

  • Process Control: Analyzing the inducements (such as bromine dosage, reaction temperature) 

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com




Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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