BAY 73-6691 NEW
| Price | $690 | $897 | $1490 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: BAY 73-6691 | CAS No.: 794568-92-6 |
| Supply Ability: 10g | Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | BAY 73-6691 |
| Description | BAY 73-6691 is an inhibitor of brain penetrant PDE9A. |
| In vitro | BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ25-35. The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ25-35 treatment. The BAY 73-6691 attenuates Aβ25-35-induced increase of apoptosis cells[1]. It is found that when SH-SY5Y cells are cultured by Aβ25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 at 200 μg/mL almost neutralizes Aβ25-35-induced oxidative damage. |
| In vivo | BAY 73-6691 significantly enhances the performance of Aβ25-35-injected mice in learning tasks from days 7 to 10 (day 7, F(5,54)=65.153; day 8, F(5,54)=62.340; day 9, F(5,54)=37.529; day 10, F(5,54)=38.624; P<0.001), and dose-dependently reverses the Aβ25-35-triggered reduction in dwell time by the 10th day post-injection (day 10, F(5,54)=27.360, P<0.001). Furthermore, a 3 mg/kg dosage nearly completely negates the delay in escape-latency observed on days 9 to 10, indicating that BAY 73-6691 mitigates the adverse effects induced by Aβ25-35 injections on these measures. Importantly, BAY 73-6691 does not affect swimming speed, demonstrating that its beneficial effects are not due to changes in motor skills. Similarly, in control (sham) mice, BAY 73-6691 does not impair spatial memory or affect four specified indices, nor does it significantly influence hippocampal neuron apoptosis, underscoring its safety and specificity in targeting Aβ25-35-related cognitive disruptions without altering normal hippocampal function[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 160 mg/mL (448.52 mM), Sonication and heating are recommended. |
| Keywords | PDE9A | BAY 73-6691 | BAY 736691 | BAY 73 6691 |
| Inhibitors Related | Theophylline monohydrate | Acefylline | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Sildenafil citrate | Doxofylline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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