BAY 73-6691 NEW
| Price | $690 | $897 | $1490 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: BAY 73-6691 | CAS No.: 794568-92-6 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | BAY 73-6691 |
| Description | BAY 73-6691 is an inhibitor of brain penetrant PDE9A. |
| In vitro | BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ25-35. The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ25-35 treatment. The BAY 73-6691 attenuates Aβ25-35-induced increase of apoptosis cells[1]. It is found that when SH-SY5Y cells are cultured by Aβ25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 at 200 μg/mL almost neutralizes Aβ25-35-induced oxidative damage. |
| In vivo | BAY 73-6691 significantly enhances the performance of Aβ25-35-injected mice in learning tasks from days 7 to 10 (day 7, F(5,54)=65.153; day 8, F(5,54)=62.340; day 9, F(5,54)=37.529; day 10, F(5,54)=38.624; P<0.001), and dose-dependently reverses the Aβ25-35-triggered reduction in dwell time by the 10th day post-injection (day 10, F(5,54)=27.360, P<0.001). Furthermore, a 3 mg/kg dosage nearly completely negates the delay in escape-latency observed on days 9 to 10, indicating that BAY 73-6691 mitigates the adverse effects induced by Aβ25-35 injections on these measures. Importantly, BAY 73-6691 does not affect swimming speed, demonstrating that its beneficial effects are not due to changes in motor skills. Similarly, in control (sham) mice, BAY 73-6691 does not impair spatial memory or affect four specified indices, nor does it significantly influence hippocampal neuron apoptosis, underscoring its safety and specificity in targeting Aβ25-35-related cognitive disruptions without altering normal hippocampal function[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 160 mg/mL (448.52 mM), Sonication and heating are recommended. |
| Keywords | PDE9A | BAY 73-6691 | BAY 736691 | BAY 73 6691 |
| Inhibitors Related | Theophylline monohydrate | Acefylline | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Sildenafil citrate | Doxofylline |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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