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CBR-5884

CBR-5884 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:CBR-5884
CAS:681159-27-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:CBR-5884
CAS:681159-27-3
Purity:99.97% Package:2mg;39USD|5mg;63USD|10mg;97USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:CBR-5884
CAS:681159-27-3
Purity:99% Package:5KG;1KG Remarks:CBR-5884
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:CBR-5884
CAS:681159-27-3
Purity:98% Package:10mg Remarks:V5026
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:CBR-5884
CAS:681159-27-3
Purity:99.97% Package:2mg;39USD|5mg;63USD|10mg;97USD

CBR-5884 manufacturers

  • CBR-5884
  • CBR-5884 pictures
  • $39.00 / 2mg
  • 2025-07-16
  • CAS:681159-27-3
  • Min. Order:
  • Purity: 99.97%
  • Supply Ability: 10g
  • CBR-5884
  • CBR-5884 pictures
  • $39.00 / 2mg
  • 2025-07-09
  • CAS:681159-27-3
  • Min. Order:
  • Purity: 99.97%
  • Supply Ability: 10g
CBR-5884 Basic information
Product Name:CBR-5884
Synonyms:CBR-5884;Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate;CBR 5884;CBR5884;ethyl 4-(cyanosulfanyl)-5-(furan-2-amido)-3-methylthiophene-2-carboxylate;2-Thiophenecarboxylic acid, 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-, ethyl ester;CBR 5884,inhibit,CBR-5884,Inhibitor,CBR5884;Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate;CBR-5884, 10 mM in DMSO
CAS:681159-27-3
MF:C14H12N2O4S2
MW:336.39
EINECS:
Product Categories:
Mol File:681159-27-3.mol
CBR-5884 Structure
CBR-5884 Chemical Properties
Boiling point 378.1±42.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 50 mg/ml) or in DMF (up to 50 mg/ml).
pka11.25±0.70(Predicted)
form paste
color white to beige
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.
Safety Information
MSDS Information
CBR-5884 Usage And Synthesis
DescriptionCBR-5884 (681159-27-3) is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM.1?The action of PHGDH is the first committed step of serine biosynthesis2?and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents.1
UsesCBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.
Biochem/physiol ActionsCBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.
References1) Mullarky?et al. (2016),?Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers; Proc. Natl. Acad. Sci. USA,?113?1778 2) Snell et al.?(1986),?The duality of pathways for serine biosynthesis is a fallacy; Trends Biochem. Sci.,?11(6)?241 3) DeNicola?et al. (2015),?NFR2 regulates serine biosynthesis in non-small cell lung cancer; Nat. Genet.,?47?1475
CBR-5884 Preparation Products And Raw materials
Tag:CBR-5884(681159-27-3) Related Product Information
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