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Postion:Product Catalog >CBR-5884
CBR-5884
  • CBR-5884

CBR-5884 NEW

Price $39 $63 $97
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-16

Product Details

Product Name: CBR-5884 CAS No.: 681159-27-3
Purity: 99.97% Supply Ability: 10g
Release date: 2025/07/16

Product Introduction

Bioactivity

NameCBR-5884
DescriptionCBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
In vitroCBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits the proliferation of breast cancer lines with high serine synthesis propensity, as well as melanoma.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 47 mg/mL (139.72 mM), Sonication is recommended.
H2O : < 0.1 mg/mL (insoluble)
Keywordsserine synthesis | PHGDH | Inhibitor | inhibit | CBR-5884 | CBR5884 | CBR 5884
Inhibitors RelatedDisulfiram | Methotrexate | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Mycophenolic acid | Methotrexate disodium | Benzyl alcohol | Isomalt | Isoniazid | Ivosidenib
Related Compound LibrariesBioactive Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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