| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Anti-infective agent 5
CAS:2738381-47-8
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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Imidazo[1,2-a]pyrazin-8(7H)-one, 2-nitro-7-[[4-(3-pyridinyl)phenyl]methyl]- manufacturers
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| | Imidazo[1,2-a]pyrazin-8(7H)-one, 2-nitro-7-[[4-(3-pyridinyl)phenyl]methyl]- Basic information |
| | Imidazo[1,2-a]pyrazin-8(7H)-one, 2-nitro-7-[[4-(3-pyridinyl)phenyl]methyl]- Chemical Properties |
| Boiling point | 666.2±65.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | pka | 4.83±0.10(Predicted) |
| | Imidazo[1,2-a]pyrazin-8(7H)-one, 2-nitro-7-[[4-(3-pyridinyl)phenyl]methyl]- Usage And Synthesis |
| Uses | Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1]. | | in vivo | Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. | Animal Model: | BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage; 50 mg/kg twice daily for five days | | Result: | Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
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| | IC 50 | Trypanosoma | | References | [1] Ang CW, et al. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. J Med Chem. 2022 Sep 16. DOI:10.1021/acs.jmedchem.2c00972 |
| | Imidazo[1,2-a]pyrazin-8(7H)-one, 2-nitro-7-[[4-(3-pyridinyl)phenyl]methyl]- Preparation Products And Raw materials |
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