- DSM265
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- $64.00 / 5mg
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2025-07-25
- CAS:1282041-94-4
- Min. Order:
- Purity: 99.79%
- Supply Ability: 10g
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| Product Name: | DSM265 | | Synonyms: | DSM265;DSM265;DSM265;DSM265;2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine;DSM265,DSM-265;2-(1,1-Difluoroethyl)-5-methyl-N-(4-(pentafluoro-l6-sulfaneyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;DSM265, 10 mM in DMSO | | CAS: | 1282041-94-4 | | MF: | C14H12F7N5S | | MW: | 415.33 | | EINECS: | 826-984-9 | | Product Categories: | API | | Mol File: | 1282041-94-4.mol |  |
| | DSM265 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:50.0(Max Conc. mg/mL);120.39(Max Conc. mM) | | form | A solid | | color | White to off-white |
| | DSM265 Usage And Synthesis |
| Uses | DSM265, inhibits the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. It is also a PfDHODH inhibitor with an IC50 of 8.9 nM. | | in vivo | DSM265 (0.5 to 75 mg/kg; Oral administration; twice daily; for 4 days; NOD-scid IL-2Rγnull (NSG) mice) has potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). The maximum rate of parasite killing occurred at and above a dose of 13 mg/kg per day (6.4 mg/kg twice daily).
DSM265 has moderate terminal elimination half-life (t1/2) of 2-4 hours for mice (0.5 to 75 mg/kg, oral) [2]. | Animal Model: | NOD-scid IL-2Rγnull (NSG) mice (23-36 g)[2] | | Dosage: | 0.5 to 75 mg/kg | | Administration: | Oral administration; twice daily; for 4 days | | Result: | Had potent antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily).
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| | IC 50 | Plasmodium |
| | DSM265 Preparation Products And Raw materials |
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