化合物PF6260933
| 中文名稱(chēng) | 化合物PF6260933 |
|---|---|
| 中文同義詞 | 化合物PF6260933;5-(4-氯苯基)-[3,3'-聯(lián)吡啶]-6,6'-二胺;化合物PF6260933,10 MM DMSO 溶液;PF-06260933 (PF 6260933;PF6260933);PF-06260933#信號(hào)通路;PF-06260933#信號(hào)通路 |
| 英文名稱(chēng) | PF-6260933 |
| 英文同義詞 | PF-6260933;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF06260933;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933;5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine;PF-06260933, 10 mM in DMSO;PF-06260933 (PF 6260933 |
| CAS號(hào) | 1811510-56-1 |
| 分子式 | C16H13ClN4 |
| 分子量 | 296.75 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 1811510-56-1.mol |
| 結(jié)構(gòu)式 |  |
化合物PF6260933 性質(zhì)
| 沸點(diǎn) | 483.8±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.330±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | DMF：1 mg/ml； DMSO：1 mg/ml；乙醇：insol； PBS (pH 7.2)：不溶 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 5.04±0.13(Predicted) |
| 顏色 | 白色至米白色 |
PF-6260933 (PF-06260933)是MAP4K4抑制劑，IC50為3.7 nM，具有良好的激酶組選擇性。
| Target | Value |
|
MAP4K4
() | 3.7 nM |
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.
安全信息
| 海關(guān)編碼 | 2933998090 |
|---|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-19562 | 化合物PF6260933 PF-06260933 | 1811510-56-1 | 1 mg | 541元 |
| 2025/05/22 | HY-19562 | 化合物PF6260933 PF-06260933 | 1811510-56-1 | 5 mg | 1200元 |