1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE manufacturers
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| | 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE Basic information |
| Product Name: | 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE | | Synonyms: | tert-Butyl N-(3-amino-2,2-dimethylpropyl)carbamate;N-Boc-2,2-dimethyl-1,3-diaminopropane;CarbaMic acid, N-(3-aMino-2,2-diMethylpropyl)-, 1,1-diMethylethyl ester;N-Boc-2,2-dimethyl-1,3-propanediamine
tert-Butyl (3-Amino-2,2-dimethylpropyl)carbamate
(3-Amino-2,2-dimethylpropyl)carbamic Acid tert-Butyl Ester
N-Boc-2,2-dimethyl-1,3-diaminopropane;N-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-propanediamine;1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE;BOC-1-AMINO-2,2-DIMETHYL-1,3-PROPYLDIAMINE;(3-Amino-2,2-dimethylpropyl)carbamic Acid tert-Butyl Ester | | CAS: | 292606-35-0 | | MF: | C10H22N2O2 | | MW: | 202.29 | | EINECS: | | | Product Categories: | Monoprotected Diaminoalkanes;N-Boc-diaminoalkanes;pharmacetical;N-BOC | | Mol File: | 292606-35-0.mol |  |
| | 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE Chemical Properties |
| Melting point | 74 °C | | Boiling point | 293.8±23.0 °C(Predicted) | | density | 0.964±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 12.86±0.46(Predicted) | | form | powder to crystal | | color | White to Almost white | | CAS DataBase Reference | 292606-35-0(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2924.19.8000 |
| | 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE Usage And Synthesis |
| Synthesis | Di-tert-butyl dicarbonate was slowly added to a solution of 2,2-dimethylpropane-1,3-diamine in dichloromethane (DCM) (500 mL) of 2,2-dimethylpropane-1,3-diamine (80 g, 783 mmol) and di-tert-butyl dicarbonate (91 mL, 391 mmol) at 0 °C. The reaction mixture was stirred at ambient temperature for 12 hours. Subsequently, the reaction mixture was concentrated to remove the solvent. The crude product was purified by column chromatography (neutral alumina) using methanol: dichloromethane (1:9) as eluent to afford tert-butyl (3-amino-2,2-dimethylpropyl)carbamate (50 g, 247 mmol, 31.6% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 0.85 (s, 6H), 1.44 (s, 9H), 2.35-2.52 (m, 2H), 3.00 (br d, J = 6.14Hz, 2H), 5.16 (br s, 1H). | | References | [1] Patent: WO2018/109648, 2018, A1. Location in patent: Page/Page column 64
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 2, p. 236 - 246
[3] Patent: US2005/20623, 2005, A1. Location in patent: Page 116
[4] Patent: EP1550657, 2005, A1. Location in patent: Page/Page column 46 |
| | 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE Preparation Products And Raw materials |
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