那可丁
| 中文名稱 | 那可丁 |
|---|---|
| 中文同義詞 | 那可汀鹼鹽酸鹽;那可丁鹽酸鹽;那可汀鹽酸鹽水合物;那可汀 鹽酸鹽;諾司卡品 鹽酸鹽 水合物;6,7-二甲氧基-3-(4-甲氧基-6-甲基-7,8-二氫-5H-[1,3]二氧環(huán)戊并[4,5-G]異喹啉-5-基)-3H-2-苯并呋喃-1-酮鹽酸鹽;鹽酸那可丁;鹽酸那可汀 |
| 英文名稱 | NOSCAPINE HYDROCHLORIDE |
| 英文同義詞 | NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;coscopinhydrochloride;coscotabshydrochloride;key-tusscapinehydrochloride |
| CAS號(hào) | 912-60-7 |
| 分子式 | C22H24ClNO7 |
| 分子量 | 449.88 |
| EINECS號(hào) | 213-014-9 |
| 相關(guān)類(lèi)別 | 中草藥成分;小分子抑制劑;有機(jī)堿;小分子抑制劑，天然產(chǎn)物;生化試劑;通用生化試劑-天然產(chǎn)物;Inhibitors |
| Mol文件 | 912-60-7.mol |
| 結(jié)構(gòu)式 |  |
那可丁 性質(zhì)
| 熔點(diǎn) | 221-223 °C(lit.) |
|---|---|
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 易溶于水和乙醇（96%）。水溶液呈微酸性；當(dāng)溶液靜置時(shí)，遇堿可能會(huì)沉淀。 |
| 形態(tài) | Solid |
| 顏色 | 晶體 |
| Merck | 13,6752 |
| InChIKey | MFLVZFXCSKVCSH-FSKSRBAZNA-N |
| SMILES | C12=C(CCN(C)[C@@]1([H])[C@@]1([H])OC(=O)C3C(OC)=C(OC)C=CC1=3)C=C1OCOC1=C2OC.Cl |&1:6,8,r| |
| EPA化學(xué)物質(zhì)信息 | 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7) |
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Proliferation Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300?mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |
安全信息
| 提供商 | 語(yǔ)言 |
|---|---|
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英文
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那可丁 化學(xué)藥品說(shuō)明書(shū)
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | N0963 | 那可丁鹽酸鹽 水合物 Noscapine Hydrochloride Hydrate | 912-60-7 | 5g | 1120元 |