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ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic acids >5-Chlorothiophene-2-carboxylic acid

5-Chlorothiophene-2-carboxylic acid

5-Chlorothiophene-2-carboxylic acid Suppliers list
Company Name: Shanghai Rochi Pharmaceutical Co.,Ltd.
Tel: 21-38751876 +8615000076078
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Products Intro: Product Name:5-chlorothiophene-2-carboxylic acid
CAS:24065-33-6
Purity:99%min Package:1kg 5kg 10kg 25kg
Company Name: Beijing Mediking Biopharm Co., Ltd
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Email: sales01@mediking.cn
Products Intro: Product Name:5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
CAS:24065-33-6
Package:25KG;
Company Name: Suzhou Nordica Biopharma CO.,LTD
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Products Intro: Product Name:5-Chloro-2-thiophenecarboxylic acid
CAS:24065-33-6
Purity:0.99 Package:25kg;|5kg;|1kg
Company Name: Hebei Chuanghai Biotechnology Co., Ltd
Tel: +8617732866630
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Products Intro: Product Name:5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
CAS:24065-33-6
Purity:99% Package:1KG;10.00;USD
Company Name: Hebei Chuanghai Biotechnology Co,.LTD
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Products Intro: Product Name:5-Chlorothiophene-2-Carboxylic Acid
CAS:24065-33-6
Purity:99% Package:1KG;5.00;USD|10KG;3.00;USD|50KG;2.00;USD

5-Chlorothiophene-2-carboxylic acid manufacturers

5-Chlorothiophene-2-carboxylic acid Basic information
Product Name:5-Chlorothiophene-2-carboxylic acid
Synonyms:5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;AKOS B000092;2-Thiophenecarboxylic acid, 5-chloro-;Chlorothiophene-2-carboxy;5-Chlorothiophene-2-carboxylic Acid, 97+%;Rivaroxaban Impurity 40;TIMTEC-BB SBB003937;RARECHEM AL BE 0303
CAS:24065-33-6
MF:C5H3ClO2S
MW:162.59
EINECS:000-000-0
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Thiophene&Benzothiophene;Pharmaceuticals;Sulfur & Selenium Compounds;Intermediates;Miscellaneous;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiophenes;ThiophenesBuilding Blocks;Heterocycles;Heterocycle-oher series;Intermediate of Rivaroxaban;bc0001;24065-33-6
Mol File:24065-33-6.mol
5-Chlorothiophene-2-carboxylic acid Structure
5-Chlorothiophene-2-carboxylic acid Chemical Properties
Melting point 154-158 °C(lit.)
Boiling point 287.0±20.0 °C(Predicted)
density 1.466 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka3.32±0.10(Predicted)
form Powder
color Cream-yellow
BRN 118361
InChIInChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
InChIKeyQZLSBOVWPHXCLT-UHFFFAOYSA-N
SMILESC1(C(O)=O)SC(Cl)=CC=1
CAS DataBase Reference24065-33-6(CAS DataBase Reference)
NIST Chemistry Reference5-Chloro-2-thiophenecarboxylic acid(24065-33-6)
Safety Information
Hazard Codes Xi
Risk Statements 36-43-36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS XM8400000
HazardClass IRRITANT
HS Code 29349990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-Chlorothiophene-2-carboxylic acid Usage And Synthesis
Description5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is also used as a ligand to synthesise the New Mono and Binuclear Ruthenium(II) Complexes[1].
Chemical PropertiesWhite to light yellow crystal powder
UsesA metabolite of Rivaroxaban (R538000).
Uses5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:
  • rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
  • 5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones
SynthesisThe compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed.undefined

1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.
References[1] Kalaiyar Swarnalatha, Ramasamy Subramanian, Subramaniam Kamalesu . “Mono and binuclear ruthenium(II) complexes containing 5-chlorothiophene-2-carboxylic acid ligands: Spectroscopic analysis and computational studies.” Journal of Molecular Structure 1123 (2016): Pages 416-425.
Tag:5-Chlorothiophene-2-carboxylic acid(24065-33-6) Related Product Information
Rivaroxaban Impurity 43 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-Thiophenecarboxylic acid (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 41 (S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid (S)-(+)-Glycidyl Phthalimide 4-(4-NITROPHENYL)MORPHOLIN-3-ONE Rivaroxaban Impurity 36 2-Chloro-5-thiophenecarboxaldehyde Rivaroxaban Impurity 34 Rivaroxaban iMpurity 5 Rivaroxaban Impurity 38 Rivaroxaban Impurity 44 Rivaroxaban Impurity 48

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