- 4-Iodo-3-pyridinamine
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- $1.60 / 100kg
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2025-06-19
- CAS:105752-11-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- 3-Amino-4-iodopyridine
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- $0.00 / 1KG
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2025-04-04
- CAS:105752-11-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
- 4-Iodo-3-pyridinamine
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- $0.00 / 25kg
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2024-03-28
- CAS:105752-11-2
- Min. Order: 25kg
- Purity: 98%
- Supply Ability: Inquiry
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| | 3-Amino-4-iodopyridine Basic information |
| | 3-Amino-4-iodopyridine Chemical Properties |
| Melting point | 69.2-69.5°C | | Boiling point | 327.2±27.0 °C(Predicted) | | density | 2.055 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | solid | | pka | 4.79±0.18(Predicted) | | Appearance | Light yellow to brown Solid | | Sensitive | Air & Light Sensitive | | InChI | InChI=1S/C5H5IN2/c6-4-1-2-8-3-5(4)7/h1-3H,7H2 | | InChIKey | ZJRSKTXMSIVNAU-UHFFFAOYSA-N | | SMILES | C1=NC=CC(I)=C1N | | CAS DataBase Reference | 105752-11-2(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| Provider | Language |
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ALFA
| English |
| | 3-Amino-4-iodopyridine Usage And Synthesis |
| Uses | 3-Amino-4-iodopyridine is a heterocyclic derivative and can be used as a pharmaceutical intermediate. | | Definition | ChEBI: 3-amino-4-iodopyridine is an aminopyridine that is 3-aminopyridine carrying an additional iodo substituent at postion 4. It has a role as a Saccharomyces cerevisiae metabolite. It is an aminopyridine and an organoiodine compound. | | Synthesis | General procedure for the synthesis of 3-amino-4-iodopyridine from N-(4-iodo-3-pyridinyl)-2,2-dimethylpropanamide: N-(4-iodo-3-pyridinyl)-2,2-dimethylpropanamide (20.00 g, 65.76 mmol) was placed in a 2 L round-bottomed flask, and 24% sulfuric acid aqueous solution (640 mL) was added. The mixture was carefully heated to 100 °C and kept for 4 hours. The progress of the reaction was monitored by analytical HPLC. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was slowly adjusted to 7-8 with 4 N NaOH solution (~700 mL).Subsequently, saturated sodium bicarbonate solution was added and extracted with dichloromethane (3 x 500 mL). The organic phases were combined and concentrated to give 3-amino-4-iodopyridine (13.3 g, 92% yield). | | References | [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 26, p. 6519 - 6534
[2] Patent: WO2006/86609, 2006, A2. Location in patent: Page/Page column 154
[3] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 57
[4] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 1, p. 11 - 16
[5] Tetrahedron Letters, 2004, vol. 45, # 46, p. 8569 - 8573 |
| | 3-Amino-4-iodopyridine Preparation Products And Raw materials |
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