- CK-636
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- $30.00 / 5mg
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2025-07-16
- CAS:442632-72-6
- Min. Order:
- Purity: 98.88%
- Supply Ability: 10g
- CK-636
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- $5.00 / 5KG
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2019-09-04
- CAS:442632-72-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| Product Name: | CK-636 | | Synonyms: | CK-636;N-(2-(2-METHYL-1H-INDOL-3-YL)ETHYL)THIOPHENE-2-CARBOXAMIDE;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;CK-636, >=98%;CK-0944636;CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636;CK-636;CK636; CK 636 | | CAS: | 442632-72-6 | | MF: | C16H16N2OS | | MW: | 284.38 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 442632-72-6.mol |  |
| | CK-636 Chemical Properties |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | peach to light tan | | InChIKey | ACAKNPKRLPMONU-UHFFFAOYSA-N | | CAS DataBase Reference | 442632-72-6 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | CK-636 Usage And Synthesis |
| Description | CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | | In vitro | CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
| | Uses | CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization. | | Biological Activity | CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes. |
| | CK-636 Preparation Products And Raw materials |
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