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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
Tegoprazan Impurity 13 Tegoprazan Impurity 13
Roxadustat Impurity 15 Roxadustat Impurity 15
(1S,3S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H- pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen- 1-yl 2,2-dimethylbutanoate (1S,3S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H- pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen- 1-yl 2,2-dimethylbutanoate 132487-01-5 C25H40O5
3-(hydroxy(2-methyl-1H-imidazol-1-yl)methyl)-9-(hydroxymethyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one 3-(hydroxy(2-methyl-1H-imidazol-1-yl)methyl)-9-(hydroxymethyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one
Perospirone Impurity 18 Perospirone Impurity 18
Perospirone Impurity 3 Perospirone Impurity 3 1002359-81-0 C8H11NO2
Dolutegravir Impurity 13(Sodium Salt) Dolutegravir Impurity 13(Sodium Salt)
Paxlovid Impurity 10 Paxlovid Impurity 10
Fondaparinux sodium impurity 4 Fondaparinux sodium impurity 4
Ampicillin Impurity W Ampicillin Impurity W
Lasmiditan Impurity 5 Lasmiditan Impurity 5
Olodaterol Impurity 18 Olodaterol Impurity 18 2727170-18-3
Febuxostat impurity DAC Febuxostat impurity DAC
ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE 5453-88-3 C9H14O3
Olodaterol Impurity 27 Olodaterol Impurity 27
(R)-Fluvastatin EP Impurity E (R)-Fluvastatin EP Impurity E
Ethacridine Impurity 9 Ethacridine Impurity 9
isopropyl 2-(2-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate isopropyl 2-(2-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
FENOFIBRIC ACID ETHYL ESTER FENOFIBRIC ACID ETHYL ESTER 42019-08-9 C19H19ClO4
Peonidin-3-O-Sophoroside-
5-O-β-D-glucoside Peonidin-3-O-Sophoroside- 5-O-β-D-glucoside 81360-22-7 C34H43O21+
7-ADCA Impuirty 1 7-ADCA Impuirty 1
32,50-Dicarboxy-cyanoco balamin 32,50-Dicarboxy-cyanoco balamin
Olodaterol Impurity 30 Olodaterol Impurity 30
Avatrombopag Impurity 55 Avatrombopag Impurity 55 1039808-70-2 C14H16Cl2N2O3
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide 88919-22-6 C12H17N3O2S
3'-Epi Gemcitabine 3'-Epi Gemcitabine 103882-85-5 C9H11F2N3O4
4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline 183322-21-6 C12H11Cl3N2O2
4-Hydroxy Omeprazole 4-Hydroxy Omeprazole 301669-82-9 C16H17N3O3S
Benzonitrile, 2-[[4-[(3R)-3-amino-1-piperidinyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]methyl]- Benzonitrile, 2-[[4-[(3R)-3-amino-1-piperidinyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]methyl]- 1634664-96-2 C17H19N5O2
2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde 2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde 13023-73-9 C8H8O4
3-Desmethyl Istradefylline 3-Desmethyl Istradefylline 155272-04-1 C19H22N4O4
BRN 0758154 BRN 0758154 69304-48-9 C11H13IN2O5
NSC4751 NSC4751 5393-61-3 C10H10N2O2
Sts 64 Sts 64 24284-84-2 C21H27NO2
2-hydroxy-N-[3-[3-(1-piperidylmethyl)phenoxy]propyl]acetamide 2-hydroxy-N-[3-[3-(1-piperidylmethyl)phenoxy]propyl]acetamide 97900-88-4 C17H26N2O3
Benazepril Related Compound D Benazepril Related Compound D 1347874-67-2 C22H25ClN2O5
2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1R,4S)-(9CI) 2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1R,4S)-(9CI) 352226-74-5 C7H11NO2
	Tamsulosin N- methyl benzyl Impurity Tamsulosin N- methyl benzyl Impurity
Oprinone Impurity 7 Oprinone Impurity 7
Arbidol Impurity 27 Arbidol Impurity 27
N-methyl-5,6-dihydroxyindole N-methyl-5,6-dihydroxyindole 4821-00-5 C9H9NO2
Imimidistine impurity G Imimidistine impurity G
4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide 152013-26-8 C14H20ClN3O3
cleistanthin B cleistanthin B 30021-77-3 C27H26O12
lumelysergol lumelysergol 7079-87-0 C16H20N2O2
columbianetin glucopyranoside columbianetin glucopyranoside 55836-35-6 C20H24O9
5'-deoxypyridoxine 5'-deoxypyridoxine 4811-03-4 C8H11NO2
phosphoric acid phosphoric acid 790712-60-6 C16H18F6N5O5P
4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 757251-39-1 C13H12FN3O2
3-Bromo-5-chloropyrazine-2-carbonitrile 3-Bromo-5-chloropyrazine-2-carbonitrile 440124-25-4 C5HBrClN3
4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) 133330-60-6 C14H9Cl2NO
Hydroxy Varenicline Hydroxy Varenicline 357424-21-6 C13H13N3O
ethyl (2S)-pyrrolidine-2-carboxylate ethyl (2S)-pyrrolidine-2-carboxylate 5817-26-5 C7H13NO2
[2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 170729-79-0 C20H18F7NO2
Dapagliflozin Dapagliflozin 639852-30-5 C19H44O5Si4
Cabozantinib impurity 52 Cabozantinib impurity 52
Canagliflozin Impurity 71 Canagliflozin Impurity 71
N-((4-(5-methyl-2-phenyloxazol-4-yl)phenyl)sulfonyl)propionamide N-((4-(5-methyl-2-phenyloxazol-4-yl)phenyl)sulfonyl)propionamide 2242749-02-4 C19H18N2O4S
Dapoxetine impurity 67 Dapoxetine impurity 67
1-Pyrrolidinecarboxylic acid, 3,3'-dithiobis[5-[[(3-carboxyphenyl)amino]carbonyl]-, 1,1'-bis[(4-nitrophenyl)methyl] ester, (3S,3'S,5S,5'S)- 1-Pyrrolidinecarboxylic acid, 3,3'-dithiobis[5-[[(3-carboxyphenyl)amino]carbonyl]-, 1,1'-bis[(4-nitrophenyl)methyl] ester, (3S,3'S,5S,5'S)- 1401451-19-1 C40H36N6O14S2
Benzeneacetic acid, α-(hydroxymethyl)-, 9-butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, [7(S)-(1α,2β,4β,5α,7β)]- (9CI) Benzeneacetic acid, α-(hydroxymethyl)-, 9-butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, [7(S)-(1α,2β,4β,5α,7β)]- (9CI) 14861-14-4 C20H27NO4
Avatrombopag Impurity 32 Avatrombopag Impurity 32
Cisatracurium besylate impurity 18 Cisatracurium besylate impurity 18
Paclitaxel Impurity1 ABCDEFGHJKL Paclitaxel Impurity1 ABCDEFGHJKL
3-THIOPHENEPROPANAMINE, N,N-DIMETHYL-GAMMA-(1-NAPHTHALENYLOXY)-, ETHANEDIOATE(1:1) 3-THIOPHENEPROPANAMINE, N,N-DIMETHYL-GAMMA-(1-NAPHTHALENYLOXY)-, ETHANEDIOATE(1:1) 116817-26-6 C21H23NO5S
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 182230-43-9 C16H14F3N5O
Bumetanide Impurity 8 Bumetanide Impurity 8
Benzenesulfonamide, N-(2-aminoethyl)-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxy- Benzenesulfonamide, N-(2-aminoethyl)-3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxy- 448184-52-9 C19H26N6O4S
Avibactam Impurity 04 Avibactam Impurity 04
Latamoxef Impurity C Latamoxef Impurity C
Carbamic acid, [2-hydroxy-1-methyl-2-[3-(phenylmethoxy)phenyl]ethyl]-, phenylmethyl ester, [R-(R*,S*)]- (9CI) Carbamic acid, [2-hydroxy-1-methyl-2-[3-(phenylmethoxy)phenyl]ethyl]-, phenylmethyl ester, [R-(R*,S*)]- (9CI) 31301-86-7 C24H25NO4
9H-Purine-9-ethanol, 6-amino-β-methyl- 9H-Purine-9-ethanol, 6-amino-β-methyl- 20776-34-5 C8H11N5O
2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-4-one 2-amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-4-one 92440-76-1 C14H17N3O4
Edoxaban impurity ABCDEFGHJKL Edoxaban impurity ABCDEFGHJKL
(S)-3-(3-((3-chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino) propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride (S)-3-(3-((3-chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino) propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
(2R,3R)-3-amino-2-methyl-4-oxoazetidine-1-sulfonic acid (2R,3R)-3-amino-2-methyl-4-oxoazetidine-1-sulfonic acid
Osimertinib impurity01 Osimertinib impurity01
(±)-N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide monohydrochloride (±)-N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide monohydrochloride 73899-76-0 C16H25ClN2O4
Hexanoic acid, 6-chloro-3,5-dihydroxy-, (3R,5S)- Hexanoic acid, 6-chloro-3,5-dihydroxy-, (3R,5S)- 958358-67-3 C6H11ClO4
Oseltamivir  Impurity 78 Oseltamivir Impurity 78
Oseltamivir  Impurity 67 Oseltamivir Impurity 67
Ixazomib Impurity ABCDEFGHJKL Ixazomib Impurity ABCDEFGHJKL
2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]-Benzoic acid 2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]-Benzoic acid 188114-98-9 C18H19NO6S
2-Pyrazinecarboxamide, N-[(1S)-2-[[(1Z)-3-methyl-1-buten-1-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]- 2-Pyrazinecarboxamide, N-[(1S)-2-[[(1Z)-3-methyl-1-buten-1-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]- 2276538-67-9 C19H22N4O2
nicorandil trimer 07 nicorandil trimer 07 2365474-06-0 C24H27N8O9+
(S)-2-(pentylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid (S)-2-(pentylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid 1332692-49-5 C23H38N2O5S
O-Demethyl elagolix sodium O-Demethyl elagolix sodium 832720-51-1 C31H28F5N3O5
Carbazochrome Sodium Sulfonate Impurity IV (Carbazochrome Sodium Sulfonate Impurity 4) Carbazochrome Sodium Sulfonate Impurity IV (Carbazochrome Sodium Sulfonate Impurity 4)
Telmisartan EP Impurity B Complete Set Telmisartan EP Impurity B Complete Set
Atracurium Impurity G Complete Set Atracurium Impurity G Complete Set
Cetrorelix Impurity 12 Cetrorelix Impurity 12
Cetrorelix Impurity 5 (6-D-Orn) Cetrorelix Impurity 5 (6-D-Orn)
Tenofovir impurity EE Tenofovir impurity EE
Peramivir Intermediate Impurity 35 Peramivir Intermediate Impurity 35
Peramivir Intermediate Impurity 40 Peramivir Intermediate Impurity 40
Alvatrombopag Impurity 999 Alvatrombopag Impurity 999
Canagliflozin impurities 16 drops Canagliflozin impurities 16 drops
Palonosetron impurity 30XH Palonosetron impurity 30XH
Pazopanib ImpurityABCDEFGHJKL Pazopanib ImpurityABCDEFGHJKL
1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone 68047-07-4 C20H25NO2
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