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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
alpha-Hydroxy-alpha-phenylbenzeneacetic acid (3-endo)-8-azabicyclo[3.2.1]oct-3-yl ester hydrochloride alpha-Hydroxy-alpha-phenylbenzeneacetic acid (3-endo)-8-azabicyclo[3.2.1]oct-3-yl ester hydrochloride 63516-30-3 C21H24ClNO3
N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID 52980-68-4 C13H16N2O5
(2R)-N-(2,6-DIMETHYLPHENYL)-2-PIPERIDINECARBOXAMIDE (2R)-N-(2,6-DIMETHYLPHENYL)-2-PIPERIDINECARBOXAMIDE 27262-43-7 C14H20N2O
ICARISIDE B5 ICARISIDE B5 114226-08-3 C19H32O8
Atorvastatin Lactam Impurity Atorvastatin Lactam Impurity 906552-18-9 C33H35FN2O6
1,3-Bis(9H-carbazol-4-yloxy)-2-propanol (Carvedilol Impurity) 1,3-Bis(9H-carbazol-4-yloxy)-2-propanol (Carvedilol Impurity) 1276477-91-8 C27H22N2O3
Atorvastatin Lactone Diepoxide Atorvastatin Lactone Diepoxide 1046118-40-4 C33H33FN2O6
2-Carboxybenzoyl Amlodipine 2-Carboxybenzoyl Amlodipine 318465-73-5 C28H29ClN2O8
rac-trans-4-Desfluoro-4-methoxy Paroxetine Hydrochloride rac-trans-4-Desfluoro-4-methoxy Paroxetine Hydrochloride 127017-74-7 C20H24ClNO4
Des(isopropoxyethyl) Bisoprolol Des(isopropoxyethyl) Bisoprolol 62572-93-4 C13H21NO3
Desmethoxy Fluvoxamine Desmethoxy Fluvoxamine 1217216-82-4 C14H19F3N2O
4'-Deoxy Vincristine 4'-Deoxy Vincristine 68135-16-0 C46H56N4O9
Demethyl Chlorpromazine Hydrochloride Demethyl Chlorpromazine Hydrochloride 3953-65-9 C16H18Cl2N2S
6-Hydroxy-6-defluoro Ciprofloxacin 6-Hydroxy-6-defluoro Ciprofloxacin 226903-07-7 C17H19N3O4
N-(2-Succinyl) Fluvoxamine N-(2-Succinyl) Fluvoxamine 259526-43-7 C19H25F3N2O6
Methylene-Bis Paroxetine Dihydrochloride Methylene-Bis Paroxetine Dihydrochloride 606968-05-2 C39H40F2N2O6
Nicorandil N-Oxide Nicorandil N-Oxide 107833-98-7 C8H9N3O5
2-Phenyl-1-[4-(trifluoromethyl)phenyl]ethane 2-(Aminoethyl)oxime (Fluvoxamine Impurity) 2-Phenyl-1-[4-(trifluoromethyl)phenyl]ethane 2-(Aminoethyl)oxime (Fluvoxamine Impurity) 1217241-15-0 C17H17F3N2O
Pitavastatin Impurity 81 Pitavastatin Impurity 81
Vonoprazan-050-C4H4O4 Vonoprazan-050-C4H4O4 928325-69-3 C21H19ClFN3O6S
2-(4-ethylpiperazin-1-yl)-4-(4-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 2-(4-ethylpiperazin-1-yl)-4-(4-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine C24H33N3O
Rosuvastatin Impurity 163 Rosuvastatin Impurity 163
Rosuvastatin Impurity 150 Rosuvastatin Impurity 150
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1h-1,2,4-triazole 86386-76-7 C11H9F2N3O
7-PACE Impurity 1 7-PACE Impurity 1
1-(3-Cyanopyridyl-2)-2-Phenyl-4-Methylpyperazine 1-(3-Cyanopyridyl-2)-2-Phenyl-4-Methylpyperazine 61337-88-0 C17H18N4
Ertapenem Impurity E(USP) Ertapenem Impurity E(USP)
Pyrazinecarboxaldehyde, trimethyl- (9CI) Pyrazinecarboxaldehyde, trimethyl- (9CI) 186534-02-1 C8H10N2O
Acetamide, N-[4-[(2R)-3-cyano-2-methyl-1-oxopropyl]phenyl]- Acetamide, N-[4-[(2R)-3-cyano-2-methyl-1-oxopropyl]phenyl]- 2428573-45-7 C13H14N2O2
4-[6-(2-Chloroethyl)-3,6,7,8-tetrahydro-3-methylimidazo[4,5-h][1,4]benzothiazin-2-yl]butanoic acid 4-[6-(2-Chloroethyl)-3,6,7,8-tetrahydro-3-methylimidazo[4,5-h][1,4]benzothiazin-2-yl]butanoic acid 2469039-29-8 C16H21Cl2N3O2S
1-(2-Methoxyphenyl)-4-{3-[4-(2-methoxyphenyl)piperazin-1-yl] propyl}piperazine 1-(2-Methoxyphenyl)-4-{3-[4-(2-methoxyphenyl)piperazin-1-yl] propyl}piperazine
D-erythro-Pent-4-enose, 4,5-dideoxy-2,3-O-(1-methylethylidene)- (9CI) D-erythro-Pent-4-enose, 4,5-dideoxy-2,3-O-(1-methylethylidene)- (9CI) 155934-55-7 C8H12O3
Isavuconazole Impurity 41 Isavuconazole Impurity 41
Carbamic acid, N-benzoyl-N-(2-phenylethyl)-, (2R)-1-azabicyclo[2.2.2]oct-2-yl ester Carbamic acid, N-benzoyl-N-(2-phenylethyl)-, (2R)-1-azabicyclo[2.2.2]oct-2-yl ester 1798817-91-0 C23H26N2O3
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium
Bisoprolol Impurity 34 Bisoprolol Impurity 34
Flomoxef Impurity I Flomoxef Impurity I
10-deazaaminopterin 10-deazaaminopterin 52454-37-2 C20H21N7O5
7-(4-Chlorobutoxy)-1H-quinolin-2-one 7-(4-Chlorobutoxy)-1H-quinolin-2-one 913613-82-8 C13H14ClNO2
-Oxo-a-propylenanthic Acid Ethyl Ester -Oxo-a-propylenanthic Acid Ethyl Ester 96610-56-9 C12H22O3
5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine 910129-15-6 C15H22FN3O6
methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 108139-78-2 C19H18N4O6
Dehydrodeoxy Donepezil (Donepezil Impurity) Dehydrodeoxy Donepezil (Donepezil Impurity) 120013-45-8 C24H29NO2
Zolmitriptan Zolmitriptan 139264-24-7 C16H21N3O2
2,3-Dimethylstyrene 2,3-Dimethylstyrene 40243-75-2 C10H12
1,1'-Biphenyl-2-ylcarbamic acid 1,1'-Biphenyl-2-ylcarbamic acid 50443-60-2 C13H11NO2
2α,3β,23-Trihydroxyolean-12-en-28-oic acid β-D-glucopyranosyl ester 2α,3β,23-Trihydroxyolean-12-en-28-oic acid β-D-glucopyranosyl ester 62369-72-6 C36H58O10
10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide 146-21-4 C17H20N2OS
(6E,10E)-7,11,15-Trimethyl-3-methylene-1,6,10,14-hexadecatetrene (6E,10E)-7,11,15-Trimethyl-3-methylene-1,6,10,14-hexadecatetrene 70901-63-2 C20H32
4-O-[4-[[(1S)-4β,5α,6β-Trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1β-yl]amino]-4,6-dideoxy-α-D-glucopyranosyl]-D-glucose 4-O-[4-[[(1S)-4β,5α,6β-Trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1β-yl]amino]-4,6-dideoxy-α-D-glucopyranosyl]-D-glucose 68128-53-0 C19H33NO13
4-O-[4-[[(1S)-4β,5α,6β-Trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1β-yl]amino]-4,6-dideoxy-α-D-glucopyranosyl]-D-glucose 4-O-[4-[[(1S)-4β,5α,6β-Trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1β-yl]amino]-4,6-dideoxy-α-D-glucopyranosyl]-D-glucose 68128-53-0 C19H33NO13
cis-Montelukast cis-Montelukast 774538-96-4 C35H36ClNO3S
(S)-(-)-Tolvaptan (S)-(-)-Tolvaptan 331947-44-5 C26H25ClN2O3
N-tert-Butoxycarbonyl Mirabegron N-tert-Butoxycarbonyl Mirabegron 1329485-55-3 C26H32N4O4S
Crisaborole Impurity 45 Crisaborole Impurity 45 1785498-37-4 C7H6Br2O
Sugammadex Impurity 26(Org199129-1) Sugammadex Impurity 26(Org199129-1) 2412953-06-9
Gadobutrol Impurity A Gadobutrol Impurity A
Levocarnitine EP Impurity A(Z) Levocarnitine EP Impurity A(Z)
Penicillin impurity E Penicillin impurity E
2-bromo-6-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile 2-bromo-6-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(2-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate tert-butyl 2-((4R,6S)-6-((E)-2-(4-(2-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
methyl (3aR,4S,6R,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3- yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate methyl (3aR,4S,6R,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3- yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
3-Pyridinecarboxamide, 5-chloro-N-[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]-1,6-dihydro-6-oxo-, hydrochloride (1:) 3-Pyridinecarboxamide, 5-chloro-N-[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]-1,6-dihydro-6-oxo-, hydrochloride (1:) 570403-05-3 C23H26Cl3N5O2S2
Avatrombopag Impurity 49 Avatrombopag Impurity 49
Avatrombopag Impurity 56 Avatrombopag Impurity 56
Pterosin A-2-O-glucoside Pterosin A-2-O-glucoside
2-(4-(2-(4-(1-(2-hydroxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid 2-(4-(2-(4-(1-(2-hydroxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid C26H33N3O3
Ampicillin Impurity C2 Ampicillin Impurity C2
Tegoprazan Impurity 13 Tegoprazan Impurity 13
Nirmatrelvir Impurity 6 Nirmatrelvir Impurity 6
Bumetanide Impurity 25 Bumetanide Impurity 25
Rocuronium Bromide Impurity 16 、17、18 Rocuronium Bromide Impurity 16 、17、18
Roxadustat Impurity 15 Roxadustat Impurity 15
(1S,3S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H- pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen- 1-yl 2,2-dimethylbutanoate (1S,3S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H- pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen- 1-yl 2,2-dimethylbutanoate 132487-01-5 C25H40O5
3-(hydroxy(2-methyl-1H-imidazol-1-yl)methyl)-9-(hydroxymethyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one 3-(hydroxy(2-methyl-1H-imidazol-1-yl)methyl)-9-(hydroxymethyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one
Perospirone Impurity 18 Perospirone Impurity 18
Perospirone Impurity 3 Perospirone Impurity 3 1002359-81-0 C8H11NO2
Dolutegravir Impurity 13(Sodium Salt) Dolutegravir Impurity 13(Sodium Salt)
Paxlovid Impurity 10 Paxlovid Impurity 10
Fondaparinux sodium impurity 4 Fondaparinux sodium impurity 4
Ampicillin Impurity W Ampicillin Impurity W
Lasmiditan Impurity 5 Lasmiditan Impurity 5
Olodaterol Impurity 18 Olodaterol Impurity 18 2727170-18-3
Febuxostat impurity DAC Febuxostat impurity DAC
ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE 5453-88-3 C9H14O3
Olodaterol Impurity 27 Olodaterol Impurity 27
(R)-Fluvastatin EP Impurity E (R)-Fluvastatin EP Impurity E
Ethacridine Impurity 9 Ethacridine Impurity 9
isopropyl 2-(2-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate isopropyl 2-(2-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
32,50-Dicarboxy-cyanoco balamin 32,50-Dicarboxy-cyanoco balamin
Olodaterol Impurity 30 Olodaterol Impurity 30
Avatrombopag Impurity 55 Avatrombopag Impurity 55 1039808-70-2 C14H16Cl2N2O3
3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide 3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide 88919-22-6 C12H17N3O2S
3'-Epi Gemcitabine 3'-Epi Gemcitabine 103882-85-5 C9H11F2N3O4
4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline 183322-21-6 C12H11Cl3N2O2
4-Hydroxy Omeprazole 4-Hydroxy Omeprazole 301669-82-9 C16H17N3O3S
Benzonitrile, 2-[[4-[(3R)-3-amino-1-piperidinyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]methyl]- Benzonitrile, 2-[[4-[(3R)-3-amino-1-piperidinyl]-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]methyl]- 1634664-96-2 C17H19N5O2
2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde 2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde 13023-73-9 C8H8O4
NSC4751 NSC4751 5393-61-3 C10H10N2O2
Sts 64 Sts 64 24284-84-2 C21H27NO2
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