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Analytical Chemistry

Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure Chemical Name CAS MF
sofosBuvir impurity 1 sofosBuvir impurity 1
2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid 2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid 144060-52-6 C15H14N2O3S
Alogliptin Related Compound 26 Alogliptin Related Compound 26 865759-10-0 C25H24N6O2
R-Tirofiban R-Tirofiban 158808-86-7 C22H36N2O5S
Canagliflozin Impurity 20 Canagliflozin Impurity 20
Canagliflozin Impurity 6 Canagliflozin Impurity 6
Carfilzomib Impurity 6 Carfilzomib Impurity 6
Daclatasvir Impurity 5 (SRSS-Isomer) Daclatasvir Impurity 5 (SRSS-Isomer) 1009117-28-5 C40H50N8O6
Dolutegravir Impurity 7 Dolutegravir Impurity 7 2244161-71-3 C20H21N3O5
Istradefylline Impurity F Istradefylline Impurity F
Linagliptin Impurity 22 Linagliptin Impurity 22
Nintedanib impurity G Nintedanib impurity G 894783-61-0 C30H31N5O4
3,3′-[(2-methylbenzene-1,3-diyl)bis(oxy)]bis(N-methyl- 3-phenylpropan-1-amine) 3,3′-[(2-methylbenzene-1,3-diyl)bis(oxy)]bis(N-methyl- 3-phenylpropan-1-amine) 1010818-93-5 C27H34N2O2
Febuxostat impurity 36 Febuxostat impurity 36 1805770-40-4 C12H12N2O
N-[1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]- 2-Propenamide N-[1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]- 2-Propenamide 2031255-27-1 C28H26N6O3
4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one C8H11FN3O4S-
Anastrozole Impurity 3 Anastrozole Impurity 3
Cephalexin Impurity 4 Cephalexin Impurity 4 C16H17N3O4S
2-(DIETHYLAMINO)-N-(2,4-DIMETHYLPHENYL)ACETAMIDE 2-(DIETHYLAMINO)-N-(2,4-DIMETHYLPHENYL)ACETAMIDE 17289-53-1 C14H22N2O
Olaparib Impurity A Olaparib Impurity A
Dapoxetine Impurity 2 Dapoxetine Impurity 2
Voriconazole Impurity 5 Voriconazole Impurity 5
tetrahydrofuran-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate tetrahydrofuran-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate 1404453-75-3 C17H22O4
Lamivudine impurity 5 Lamivudine impurity 5
Clopidogrel Impurity 2 Clopidogrel Impurity 2 C15H14ClNO2S
Mirabegron Impurity 6 Mirabegron Impurity 6 2762802-64-0 C10H11ClN4O3S2
Pitavastatin Impurity 3 Pitavastatin Impurity 3
Solifenacin EP Impurity D Solifenacin EP Impurity D
Cephalexin Impurity 2 Cephalexin Impurity 2 C16H17N3O4S
Cefuroxime Impurity 3 Cefuroxime Impurity 3 C16H16N4O8S
Vonoprazan Impurity 11 Vonoprazan Impurity 11
Atracurium Impurity A Atracurium Impurity A 2724465-40-9 C28H39NO7
Erlotinib Imp.14 Erlotinib Imp.14
Sorafenib related compound 12 Sorafenib related compound 12 284461-74-1 C20H14ClF3N4O3
Apremilast Impurity 10 Apremilast Impurity 10 1809170-71-5 C22H26N2O8S
(1R,3S)-Solifenacin Succinate (1R,3S)-Solifenacin Succinate 774517-20-3 C23H26N2O2
Dacpomycin Impurity 2 Dacpomycin Impurity 2
Nicorandil Impurity 3 Nicorandil Impurity 3
Tacrolimus Impurity A Tacrolimus Impurity A
1H-Benz[de]isoquinolin-1-one,2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-,(3aR)- 1H-Benz[de]isoquinolin-1-one,2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-,(3aR)- 135729-73-6 C19H24N2O
Afatinib Impurity 16 Afatinib Impurity 16
Mirabegron Impurity 19 Mirabegron Impurity 19
(Z)-Mutagenic Impurity of Tenofovir Disoproxil (Z)-Mutagenic Impurity of Tenofovir Disoproxil 1464851-21-5 C8H9N5
Rivaroxaban Impurity 42 Rivaroxaban Impurity 42
(R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoic acid (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoic acid 1422514-05-3 C22H26FN3O6S
Atorvastatin 2-Fluoro t-Butyl Ester Atorvastatin 2-Fluoro t-Butyl Ester 1099474-28-8 C40H47FN2O5
Cabozantinib Impurity C Cabozantinib Impurity C
(3R,4R)-N,4-dimethyl-piperidin-3-amine (3R,4R)-N,4-dimethyl-piperidin-3-amine 1354469-76-3 C7H16N2
4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine 4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine 952518-97-7 C9H7N5
5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 881676-90-0 C16H12N2O3S
3-Piperidinemethanol, 4-(4-fluorophenyl)-1-methyl-, (3R,4R)- 3-Piperidinemethanol, 4-(4-fluorophenyl)-1-methyl-, (3R,4R)- 100332-12-5 C13H18FNO
r-Cytidine r-Cytidine 13913-16-1 C9H13N3O5
Pyridine, 4-chloro-2-(chloromethyl)-3-methyl- Pyridine, 4-chloro-2-(chloromethyl)-3-methyl- 168167-48-4 C7H7Cl2N
1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol 1,2,4-Triazolo(3,4-b)benzothiazole-5-methanol 69243-49-8 C9H7N3OS
Benzoicacid, 2-sulfino- Benzoicacid, 2-sulfino- 13165-80-5 C7H6O4S
Benzenemethanamine, a-ethyl-N,N-dimethyl- Benzenemethanamine, a-ethyl-N,N-dimethyl- 3330-05-0 C11H17N
CIS-1,2-BIS(AMINOMETHYL)CYCLOBUTANE CIS-1,2-BIS(AMINOMETHYL)CYCLOBUTANE 15286-88-1 C6H14N2
O-DesmethylApixabanSulphateNa O-DesmethylApixabanSulphateNa 1118765-14-2 C24H23N5O7S
4-Chloro-2-fluoro-N-methylbenzamide 4-Chloro-2-fluoro-N-methylbenzamide 1343038-33-4 C8H7ClFNO
N-FORMYL-1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL)CYCLOHEXANOL N-FORMYL-1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL)CYCLOHEXANOL 272788-07-5 C16H23NO3
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethan-1-amine 2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethan-1-amine 1353100-18-1 C13H18ClNO
Acotiamide  Impurity Acotiamide Impurity 198470-83-6 C20H21N2NaO4S
Terbutaline  Impurity Terbutaline Impurity 52144-90-8 C26H29NO3
methyl (41S,12R,13aR)-13a-ethyl-12-
hydroxy-2,3,41,5,6,12,13,13aoctahydro-
1H-indolo[3,2,1-
de]pyrido[3,2,1-ij][1,5]naphthyridine-
12-carboxylate methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate 83508-83-2 C21H26N2O3
ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 473465-11-1 C18H18N2O3S
Mouse Neonatal Thyroxine,NN-T4 ELISA Kit Mouse Neonatal Thyroxine,NN-T4 ELISA Kit
Ropivacaine-iPr-R Ropivacaine-iPr-R 1050482-18-2 C17H26N2O
Demiditraz IMpurity Demiditraz IMpurity 944268-66-0 C20H22N2O
AcarBose EP Impurity B AcarBose EP Impurity B 1220983-54-9 C26H43NO17
Alogliptin Impurity 17 Alogliptin Impurity 17
Aprepitant Impurity 15 Aprepitant Impurity 15 1447693-83-5 C20H19ClF7NO2
Betamethasone EP Impurity H Betamethasone EP Impurity H 185613-71-2 C22H29FO5
Blonanserin Impurity 10 Blonanserin Impurity 10 132810-87-8 C23H30ClN3
Blonanserin impurity G Blonanserin impurity G
Cefodizime Impurity 5 Cefodizime Impurity 5
Clindamycin Impurity 4 Clindamycin Impurity 4
Doxofylline Impurity 4 Doxofylline Impurity 4 2095554-12-2 C11H16N4O5
Eltrombopag Impurity 1 Eltrombopag Impurity 1 1246929-02-1 C25H23N5O3
Everolimus impurity A Everolimus impurity A
Fosaprepitant Impurity 13 Fosaprepitant Impurity 13
Gefitinib Impurity J Gefitinib Impurity J
Isavuconazole Impurity 23 Isavuconazole Impurity 23
Isavuconazole Impurity 29 Isavuconazole Impurity 29
Isavuconazole Impurity 7 Isavuconazole Impurity 7
Lercanidipine Impurity 6 Lercanidipine Impurity 6 786625-22-7 C37H43N3O6
Linagliptin Impurity 43 Linagliptin Impurity 43
MiraBegron Impurity A MiraBegron Impurity A
Moxifloxacin Impurity 15 Moxifloxacin Impurity 15
Moxifloxacin Impurity 32 Moxifloxacin Impurity 32
Nifedipine Impurity F Nifedipine Impurity F 53055-15-5 C18H20N2O6
Olaparib Impurity 15 Olaparib Impurity 15 2250243-17-3 C24H25FN4O3
Ethylmethyl-carbamic chloride Ethylmethyl-carbamic chloride 42252-34-6 C4H8ClNO
N-(3-{[(4-methylphenyl)sulfonyl]amino}phenyl)acetamide N-(3-{[(4-methylphenyl)sulfonyl]amino}phenyl)acetamide 329941-39-1 C15H16N2O3S
Cisatracurium-20-methyl Dibenzenesulfonate Cisatracurium-20-methyl Dibenzenesulfonate 1193104-85-6 C60H79N2O15S+
[R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE [R-(R*,S*)]-(-)-N-(1-PHENYLETHYL)-1-AZABICYCLO[2.2.2]OCTAN-3-AMINE DIHYDROCHLORIDE 128311-06-8 C15H24Cl2N2
GURKHSYORGJETM-MGDILKBHSA-N GURKHSYORGJETM-MGDILKBHSA-N 1992961-26-8 C33H39ClN4O6
DVCUGHHGLKCBMT-QVDQXJPCSA-N DVCUGHHGLKCBMT-QVDQXJPCSA-N 1356353-76-8 C15H24N6O6
5,6-Dehydro-Tigecycline 5,6-Dehydro-Tigecycline 1633815-62-9 C29H37N5O8
2,3,5,6-tetradeuterio-4-[5-[4-(hydroxymethyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide 2,3,5,6-tetradeuterio-4-[5-[4-(hydroxymethyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide 1276524-56-1 C17H10D4F3N3O3S
1,1-diphenylpropan-1-ol 1,1-diphenylpropan-1-ol 5180-33-6 C15H16O
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