BB-Cl-Amidine
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3物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
- 500μg
- 1mg
- 5mg
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號W01CAY17079
- 製品説明
- 英語製品説明BB-Cl-Amidine
- 包裝単位5mg
- 価格￥47300
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號W01CAY17079
- 製品説明
- 英語製品説明BB-Cl-Amidine
- 包裝単位500μg
- 価格￥22800
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號W01CAY17079
- 製品説明
- 英語製品説明BB-Cl-Amidine
- 包裝単位1mg
- 価格￥19000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會(huì)社(wako) | W01CAY17079 | BB-Cl-Amidine |
5mg | ￥47300 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01CAY17079 | BB-Cl-Amidine |
500μg | ￥22800 | 2021-03-23 | 購入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01CAY17079 | BB-Cl-Amidine |
1mg | ￥19000 | 2024-03-01 | 購入 |
プロパティ
貯蔵溫度 :Inert atmosphere,Store in freezer, under -20°C
溶解性 :DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM)
Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) 外見 :A crystalline solid
色 :white to beige
InChIKey :YDOAWJHYHGBQFI-QHCPKHFHSA-N
SMILES :C1(C2=CC=CC=C2)=CC=C(C(N[C@H](C2NC3=CC=CC=C3N=2)CCCNC(=N)CCl)=O)C=C1
溶解性 :DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM)
Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) 外見 :A crystalline solid
色 :white to beige
InChIKey :YDOAWJHYHGBQFI-QHCPKHFHSA-N
SMILES :C1(C2=CC=CC=C2)=CC=C(C(N[C@H](C2NC3=CC=CC=C3N=2)CCCNC(=N)CCl)=O)C=C1
安全情報(bào)
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| 注意喚起語: | Warning | |||||||||||||||||||||||||||||||||||
| 危険有害性情報(bào): |
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説明
Protein arginine deiminase 4 (PAD4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which can alter gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. Cl-amidine is an inhibitor of PAD4 deimination activity with an IC50 value of 5.9 μM in an in vitro activity assay. BB-Cl-Amidine is a Cl-amidine derivative that retains functional components but possesses a C-terminal benzimidazole designed to limit proteolysis of the C-terminal amide. The cellular potency of BB-Cl-amidine against PAD4 activity is increased 20-fold over the parent compound (EC50 = 8.8 μM, vs. >200 μM for Cl-amidine). BB-Cl-Amidine also has a significantly longer in vivo half-life than Cl-amidine (1.75 h vs. ~15 min, respectively). Both compounds inhibit the formation of neutrophil extracellular traps without altering H2O2 production by neutrophils. BB-Cl-Amidine is effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice.供給者とメーカー
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