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ChemicalBook >> CAS DataBase List >> BB-Cl-Amidine

BB-Cl-Amidine

BB-Cl-Amidine price.
  • $68 - $4400
  • Product name: BB-Cl-Amidine
  • CAS: 1802637-39-3
  • MF: C26H26ClN5O
  • MW: 459.971
  • EINECS:
  • MDL Number:MFCD31746879
  • Synonyms:BB-Cl-Amidine;CS-2826;N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-;Peptidylarginine Deiminase,Inhibitor,BBClAmidine,BB Cl Amidine,Protein Arginine Deiminase,inhibit;(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide;N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-4-(2-chloroethanimidamido)butyl]-[1,1'-biphenyl]-4-carboxamide
10 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • Cayman Chemical
  • DC Chemicals
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number6591EJ
  • Product descriptionBB-Cl-Amidine
  • Packaging1mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1001784
  • Product description(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+%
  • Packaging50mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1001784
  • Product description(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+%
  • Packaging100mg
  • Price$612
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1001784
  • Product description(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+%
  • Packaging250mg
  • Price$1102
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1001784
  • Product description(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+%
  • Packaging1g
  • Price$3745
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17079
  • Product descriptionBB-Cl-Amidine ≥95%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17079
  • Product descriptionBB-Cl-Amidine ≥95%
  • Packaging500μg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17079
  • Product descriptionBB-Cl-Amidine ≥95%
  • Packaging5mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17079
  • Product descriptionBB-Cl-Amidine ≥95%
  • Packaging10mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC12280
  • Product descriptionBB-Cl-Amidine >98%
  • Packaging1g
  • Price$4400
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6591EJ BB-Cl-Amidine 1mg $313 2021-12-16 Buy
Ambeed A1001784 (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+% 50mg $340 2021-12-16 Buy
Ambeed A1001784 (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+% 100mg $612 2021-12-16 Buy
Ambeed A1001784 (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+% 250mg $1102 2021-12-16 Buy
Ambeed A1001784 (S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide 98+% 1g $3745 2021-12-16 Buy
Cayman Chemical 17079 BB-Cl-Amidine ≥95% 1mg $68 2024-03-01 Buy
Cayman Chemical 17079 BB-Cl-Amidine ≥95% 500μg $99 2021-12-16 Buy
Cayman Chemical 17079 BB-Cl-Amidine ≥95% 5mg $169 2024-03-01 Buy
Cayman Chemical 17079 BB-Cl-Amidine ≥95% 10mg $302 2024-03-01 Buy
DC Chemicals DC12280 BB-Cl-Amidine >98% 1g $4400 2021-12-16 Buy

Properties

storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM)
Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) form :A crystalline solid
color :white to beige
InChIKey :YDOAWJHYHGBQFI-QHCPKHFHSA-N
SMILES :C1(C2=CC=CC=C2)=CC=C(C(N[C@H](C2NC3=CC=CC=C3N=2)CCCNC(=N)CCl)=O)C=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Protein arginine deiminase 4 (PAD4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which can alter gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. Cl-amidine is an inhibitor of PAD4 deimination activity with an IC50 value of 5.9 μM in an in vitro activity assay. BB-Cl-Amidine is a Cl-amidine derivative that retains functional components but possesses a C-terminal benzimidazole designed to limit proteolysis of the C-terminal amide. The cellular potency of BB-Cl-amidine against PAD4 activity is increased 20-fold over the parent compound (EC50 = 8.8 μM, vs. >200 μM for Cl-amidine). BB-Cl-Amidine also has a significantly longer in vivo half-life than Cl-amidine (1.75 h vs. ~15 min, respectively). Both compounds inhibit the formation of neutrophil extracellular traps without altering H2O2 production by neutrophils. BB-Cl-Amidine is effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice.