JH-II-127
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- $32 - $1250
- Product name: JH-II-127
- CAS: 1700693-08-8
- MF: C19H21ClN6O3
- MW: 416.86
- EINECS:
- MDL Number:MFCD28975160
- Synonyms:JH-II-127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
14 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 50
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number5830EE
- Product descriptionCID112499966
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22905
- Product descriptionJH-II-127
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22905
- Product descriptionJH-II-127
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22905
- Product descriptionJH-II-127
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22905
- Product descriptionJH-II-127
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM250231
- Product description(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98%
- Packaging100mg
- Price$987
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003021
- Product descriptionJH-II-127 98+%
- Packaging10mg
- Price$251
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003021
- Product descriptionJH-II-127 98+%
- Packaging50mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003021
- Product descriptionJH-II-127 98+%
- Packaging100mg
- Price$1250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8379
- Product descriptionJH-II-127 >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2569
- Product descriptionJH-II-127 ≥98% (HPLC)
- Packaging5MG
- Price$123
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML2569
- Product descriptionJH-II-127 ≥98% (HPLC)
- Packaging25MG
- Price$396
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number6289
- Product descriptionJH-II-127 ≥98%(HPLC)
- Packaging50
- Price$874
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberJ211303
- Product descriptionJH-II-127
- Packaging5mg
- Price$195
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5830EE | CID112499966 | 1mg | $133 | 2021-12-16 | Buy |
| Cayman Chemical | 22905 | JH-II-127 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22905 | JH-II-127 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 22905 | JH-II-127 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 22905 | JH-II-127 | 25mg | $533 | 2024-03-01 | Buy |
| Chemenu | CM250231 | (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 98% | 100mg | $987 | 2021-12-16 | Buy |
| Crysdot | CD31003021 | JH-II-127 98+% | 10mg | $251 | 2021-12-16 | Buy |
| Crysdot | CD31003021 | JH-II-127 98+% | 50mg | $750 | 2021-12-16 | Buy |
| Crysdot | CD31003021 | JH-II-127 98+% | 100mg | $1250 | 2021-12-16 | Buy |
| DC Chemicals | DC8379 | JH-II-127 >98% | 100mg | $550 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML2569 | JH-II-127 ≥98% (HPLC) | 5MG | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2569 | JH-II-127 ≥98% (HPLC) | 25MG | $396 | 2024-03-01 | Buy |
| Tocris | 6289 | JH-II-127 ≥98%(HPLC) | 50 | $874 | 2021-12-16 | Buy |
| TRC | J211303 | JH-II-127 | 5mg | $195 | 2021-12-16 | Buy |
Properties
Melting point :>166°C (dec.)
Density :1.458±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.49±0.50(Predicted)
color :White to Pale Beige
Density :1.458±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.49±0.50(Predicted)
color :White to Pale Beige
Safety Information
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Description
JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Alchem Pharmtech,Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd.
