JH-II-127 NEW
| Price | $106 | $172 | $297 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: JH-II-127 | CAS No.: 1700693-08-8 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | JH-II-127 |
| Description | JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively. |
| In vivo | JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro.?It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (71.97 mM), Sonication is recommended. |
| Keywords | Ser935 | parkinson's disease | LRRK2-G2019S | LRRK2-A2016T | LRRK2 | Leucine-rich repeat kinase 2 | JH-II-127 | JH-II127 | JHII127 | JH-II 127 | JH II 127 | Inhibitor | inhibit | HEK293 | 3T3 cells |
| Inhibitors Related | IKK 16 | PFE-360 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | GNE-7915 | EB-42486 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 | CCG-1423 |
| Related Compound Libraries | Highly Selective Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Parkinson's Disease Compound Library | Autophagy Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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