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ChemicalBook >> CAS DataBase List >> AP39

AP39

AP39 price.
  • $32 - $1240
  • Product name: AP39
  • CAS: 1429173-57-8
  • MF: C37H38O2PS3+
  • MW: 641.865
  • EINECS:
  • MDL Number:MFCD00947997
  • Synonyms:AP39;AP39 Free base
6 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number9245DU
  • Product description[10-Oxo-10-[4-(5-sulfanylidenedithiol-3-yl)phenoxy]decyl]-triphenylphosphanium
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17100
  • Product descriptionAP39 ≥95%
  • Packaging25mg
  • Price$533
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17100
  • Product descriptionAP39 ≥95%
  • Packaging10mg
  • Price$243
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17100
  • Product descriptionAP39 ≥95%
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17100
  • Product descriptionAP39 ≥95%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberA729260
  • Product descriptionAP39
  • Packaging100mg
  • Price$1240
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9245DU [10-Oxo-10-[4-(5-sulfanylidenedithiol-3-yl)phenoxy]decyl]-triphenylphosphanium 1mg $133 2021-12-16 Buy
Cayman Chemical 17100 AP39 ≥95% 25mg $533 2024-03-01 Buy
Cayman Chemical 17100 AP39 ≥95% 10mg $243 2024-03-01 Buy
Cayman Chemical 17100 AP39 ≥95% 5mg $139 2024-03-01 Buy
Cayman Chemical 17100 AP39 ≥95% 1mg $32 2024-03-01 Buy
TRC A729260 AP39 100mg $1240 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMSO: 20 mg/ml; Ethanol: 16 mg/ml; PBS (pH 7.2): 1 mg/ml

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.