AP39
- CAS No.
- 1429173-57-8
- Chemical Name:
- AP39
- Synonyms
- AP39;AP39 Free base
- CBNumber:
- CB33152549
- Molecular Formula:
- C37H38O2PS3+
- Molecular Weight:
- 641.865
- MDL Number:
- MFCD00947997
- MOL File:
- 1429173-57-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H341-H351-H335-H372 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P321-P314-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
AP39 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 25mg | $533 | 2024-03-01 | Buy |
| TRC | A729260 | AP39 | 1429173-57-8 | 100mg | $1240 | 2021-12-16 | Buy |
AP39 Chemical Properties,Uses,Production
Description
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.
Uses
AP39 is a compound used to increase the level of hydrogen sulphide within the mitochondria because of the presence of the mitochondria targeting motif (triphenylphosphonium). Also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy.
AP39 Preparation Products And Raw materials
Raw materials
Preparation Products
AP39 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24980 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27987 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |