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5608-24-2
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PRIMA-1
???(??):
PRIMA-1;NSC-281668;PRIMA-1, 10 mM in DMSO;2,2-dimethylolquinuclidin-3-one;PRIMA-1 - CAS 5608-24-2 - Calbiochem;2-Bis(hydroxymethyl)-3-quinuclidinone;2,2-Bis(hydroxymethyl)quinuclidin-3-one;2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE;P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS;7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one
CBNumber:
CB8165699
???:
C9H15NO3
??? ??:
185.22
MOL ??:
5608-24-2.mol
MSDS ??:
SDS

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146-147 °C
?? ?
353.7±17.0 °C(Predicted)
??
1.32±0.1 g/cm3(Predicted)
?? ??
Inert atmosphere,2-8°C
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H2O: >10mg/mL
?? ?? (pKa)
13.68±0.10(Predicted)
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10mg/ml? ?? ???
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Light Sensitive
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  • ?? ? ???? ?? (GHS)
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????? 36/37
WGK ?? 3
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
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?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
??????:
NFPA 704
0
2 0

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PRIMA-1 is a reactivator of p53 and inducer of apoptosis.

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Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.

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