ChemicalBook >?? ???? >??? ??>?? ???>7,8-Dihydroxyflavone

7,8-Dihydroxyflavone

7,8-Dihydroxyflavone ??? ???

?? ??:: 38183-03-8

???:: 7,8-Dihydroxyflavone

???(??):: 7,8-DHF;7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-4-benzopyrone;7,8-DIHYDROXY;7,8-Di-OH flavone;8-Dihydroxyflavone;TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;DIHYDROXYFLAVONE, 7,8-;7,8-dihydroxy Flavones

CBNumber:: CB5478886

???:: C15H10O4

??? ??:: 254.24

MOL ??:: 38183-03-8.mol

MSDS ??:: SDS

?? ?? 348

7,8-Dihydroxyflavone ??

???: 243-246°C

?? ?: 494.4±45.0 °C(Predicted)

??: 1.443±0.06 g/cm3(Predicted)

FEMA: 4830 | 7,8-DIHYDROXYFLAVONE

?? ??: Inert atmosphere,Room Temperature

???: DMSO: ???24mg/mL

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 6.86±0.40(Predicted)

??: ??? ?? ???

???: ??? ?? ?????? 1? ?? ??????. ????? ??????. DMSO ?? ??? ??? -20°C?? ?? 1?? ?? ??? ? ????.

InChI: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChIKey: COCYGNDCWFKTMF-UHFFFAOYSA-N

SMILES: C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1

LogP: 2.760 (est)

CAS ??????: 38183-03-8(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xn
?? ???? ??	22
?????	24/25
WGK ??	3
RTECS ??	DJ3004000
HS ??	2932990090

????(GHS):

?? ?:

Warning

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??	??·?? ??	?? ??	??	?? ?	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

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P261	??·?·??·???·??·...·????? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	1
0		0

7,8-Dihydroxyflavone C??? ??, ??, ??

??

7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.

??? ??

White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.

??

7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.

???? ??

7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.

7,8-Dihydroxyflavone ?? ?? ? ???

???

4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)- 4H-1-Benzopyran-4-one, 7,8-bis(benzoyloxy)-2-phenyl- Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]- Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]- 7,8-??????? 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE ?????? 7-HYDROXYFLAVONE ???? ?? ??? ?????

?? ??

7,8-Dihydroxyflavone ?? ??

???( 348)?? ??

???	??	???	??	?? ?	??
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7,8-Dihydroxyflavone ?? ??:

??? ???? ??? ???? 11-a-Hydroxy canrenone methyl ester (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE 3',4',7,8-TETRAMETHOXYFLAVONE 3,7,3',4'-TETRAMETHYLGOSSYPETIN 7,8-Dihydroxyflavone GOSSYPIN 3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-4',5-dihydroxyflavone 3,6-DIHYDROXYFLAVONE 4',5-DIHYDROXYFLAVONE 3',4'-DIHYDROXYFLAVONE 3,4',6,7-Tetramethoxy-3',5-dihydroxyflavone 4',3-DIHYDROXYFLAVONE,3,4'-DIHYDROXYFLAVONE 3,2'-DIHYDROXYFLAVONE

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