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??????? ??? ???
?? ??:
901119-35-5
???:
???????
???(??):
???????
???:
Fostamatinib
???(??):
R788;RT788;CS-883;R7935788;R-935788;R788 5MG;NSC-745942;Tavalisse);Fostatinib;R788, >=99%
CBNumber:
CB52499223
???:
C23H26FN6O9P
??? ??:
580.46
MOL ??:
901119-35-5.mol

??????? ??

???
214° - 217°C
?? ?
814.2±75.0 °C(Predicted)
??
1.496
?? ??
-20°C, Hygroscopic
???
DMSO(?? ???), ???(?? ???)
?? ?? (pKa)
1.70±0.10(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?????
???
???
InChIKey
GKDRMWXFWHEQQT-UHFFFAOYSA-N
SMILES
O1C(C)(C)C(=O)N(COP(O)(O)=O)C2=NC(NC3C(F)=CN=C(NC4=CC(OC)=C(OC)C(OC)=C4)N=3)=CC=C12
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

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Fostamatinib can be used to treat cancers that have acquired resistance to kinase inhibitors.

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Tavalisse

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???( 194)?? ??
??? ?? ??? ?? ?? ? ??
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