(R)-(+)-Ketorolac
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(R)-(+)-Ketorolac ??
- ???
- 163-170°C
- ?? ??
- -20°C
- ???
- ?????(?? ???), ???(?? ???)
- ??? ??
- ??
- ??
- ???? ????
- ??? (Optical Rotation)
- [α]/D +162 to +178°, c = 1 in methanol
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- ?? ? ???? ?? (GHS)
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(R)-(+)-Ketorolac C??? ??, ??, ??
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Off-White Solid??
(R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.??
ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic keto olac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.(R)-(+)-Ketorolac ?? ?? ? ???
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(R)-(+)-Ketorolac ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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(R)-(+)-Ketorolac ?? ??:
(S)-Ketorolac
Ketorolac Impurity 48
Ketorolac Impurity 43
Ketorolac Impurity 31
Ketorolac Impurity 24
(5-chloro-1H-pyrrol-2-yl)-phenylmethanone
Ethyl 2-(1H-pyrrol-2-yl)acetate
Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide)
Ethyl-(5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate, racemic
Ketorolac Impurity 54
4-HYDROXY KETOROLAC
Ketorolac tromethamine
Ketorolac Impurity 21
KETOROLAC EP IMPURITY H
Ketorolac EP IMpurity D
1-Descarboxy Ketorolac
Ketorolac EP IMpurity G
2,2'-BIPYRROL