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Diagnostic aid(adrenocortical insufficiency); diagnostic aid (Cushing’s syndrome); hormone (corticotropin-releasing).

Biological Functions

The primary function of corticotropin-releasing factor (CRF), a hypothalamic 41-peptide, is the regulation of the release of adrenocorticotropin hormone (ACTH) from the anterior pituitary gland, which then stimulates the release of hydrocortisone from the adrenal gland. The human peptide (hCRF) and the similar sequence found in sheep (oCRF) have been prepared by synthesis. The ovine form of the hormone, however, has replaced the human form because of its longer half-life and greater potency; hCRF is no longer commercially available.
Usually, ACTH deficiency in humans is associated with a pituitary disorder rather than with a deficiency of CRF, and oCRF can be used to distinguish between pituitary hypersecretion of ACTH (Cushing's disease) and ectopic ACTH secretion, both of which are conditions that cause a hypersecretion of hydrocortisone. In the case of ectopic ACTH secretion, the administration of oCRF will elicit little to no response in the production of ACTH and hydrocortisone. Therefore, synthetic oCRF trifluoroacetate salt is marketed as a diagnostic agent for patients with ACTH dependent Cushing's syndrome.

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Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42953	64
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9980	55
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19103	58
Gill polypeptide biopharmaceutical (dalian) co., LTD	021-61263455 13167021076	amy@glschina.com	China	9325	58
Nanjing Shizhou Biology Technology Co.,Ltd	13675144456	alan.chow@synzest.com	China	9470	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2983	58
Chengdu Jinglin Biotechnology Co., Ltd.	17711399154	3211919385@qq.com	China	1815	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29998	58

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