Cucurbitacin E
|
|
Cucurbitacin E ??
- ???
- 228-234°C
- ??
- D -59° (c = 0.7 in chloroform)
- ?? ?
- 545.56°C (rough estimate)
- ??
- 1.1059 (rough estimate)
- ???
- 1.4900 (estimate)
- ?? ??
- -20°C
- ???
- DMSO: ???15mg/mL, ??
- ??? ??
- ??
- ?? ?? (pKa)
- 8.51±0.70(Predicted)
- ??
- ???? ????
- ??? (Optical Rotation)
- [α]/D -60 to -75°, c = 0.7 (CDCl3)
- InChIKey
- NDYMQXYDSVBNLL-MUYMLXPFSA-N
- SMILES
- [C@@]12(C)C[C@@H](O)[C@]([H])([C@](O)(C)C(=O)/C=C/C(C)(C)OC(=O)C)[C@@]1(C)CC(=O)[C@@]1(C)[C@]3([H])C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,3,5,7,21,26,28,40,r|
- LogP
- 3.150 (est)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 25-22 | ||
| ????? | 1-22-45-24/25 | ||
| ????(UN No.) | 3172 | ||
| WGK ?? | 3 | ||
| RTECS ?? | RC6305500 | ||
| HS ?? | 29153900 | ||
| ?? | LD50 orally in mice: 340 mg/kg (Albert) |
Cucurbitacin E C??? ??, ??, ??
??
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.??? ??
white to beige powder??
Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.??
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.?? ??
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.Cucurbitacin E ?? ?? ? ???
???
?? ??
Cucurbitacin E ?? ??
???( 237)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 |
jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29855 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 |
sales@biopurify.com | China | 3751 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49733 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32366 | 58 |
Cucurbitacin E ?? ??:
6,10,14-?????-2-????? ???-5-??-1?,?? 1,2-????????
Cucurbitacin C
Cucurbitacin,CUCURBITACIN B(RG),CUCURBITACIN B
CUCURBITACIN D,CUCURBITACIN D WITH HPLC
ADOXAL
Calebassine
CUCURBITACIN D(SH)
Cucurbitacin IIb
CUCURBITACIN IIA
CUCURBITACIN I hplc,CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I(SH),CUCURBITACIN I
Cucurbitacin Ia,Cucurbitacin F-25-acetate
Cucurbitacin A
Cucurbitacin L
Cucurbitacin F
dihydrocucurbitacin F
Cucurbitacin H,24-epi-Cucurbitacin G,Cucurbitacin G