LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)
????(GHS):
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Warning
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P- ??
H302
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?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
??????:
P264
?? ??? ?? ??? ????.
P264
?? ??? ?? ??? ????.
P270
? ??? ??? ??? ???, ???? ???? ???.
P301+P312
??? ???? ??? ????(??)? ??? ????.
P330
?? ?????.
P501
...? ??? / ??? ?? ???.
NFPA 704
0
2
0
????? C??? ??, ??, ??
??
Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID)
introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used
antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than
piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema,
capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in
many animals. Eioavailability studies in man show undetectable plasma levels of
ampiroxicam indicating 100% conversion to piroxicam during absorption process.
Ampiroxicam has been reported to have fewer side effects on the gastric mucosa
than piroxicam.
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White Solid
??
Prodrug of Piroxicam. Anti-inflammatory.
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ChEBI: A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
