ChemicalBook >?? ???? >??? ??>??????? ? >? ??? ?? ???>5-Methyluridine

5-Methyluridine

5-Methyluridine ??? ???

?? ??:: 1463-10-1

???:: 5-Methyluridine

???(??):: RIBOTHYMIDINE;1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;1-(BETA-D-RIBOFURANOSYL)THYMINE;5-Me-U;5-Me-Ur;Methyluridine;5-methyuridine;ribosylthymine;5-methyl-uridin;THYMINERIBOSIDE

CBNumber:: CB1322473

???:: C10H14N2O6

??? ??:: 258.23

MOL ??:: 1463-10-1.mol

MSDS ??:: SDS

?? ?? 488

5-Methyluridine ??

???: 183-184 °C(lit.)

??: 1.576±0.06 g/cm3(Predicted)

?? ??: Keep in dark place,Sealed in dry,Room Temperature

???: ???(?? ??? ??, ??? ??), ?(??, ??? ??)

?? ?? (pKa): 9.55±0.10(Predicted)

??? ??: ??

??: ???

??????(pH): 9.7

??? (Optical Rotation): -8.9°(C=1 g/100ml H2O)

?? ??(λmax): 267 (pH 1)；268 (pH 13)

InChI: InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1

InChIKey: DWRXFEITVBNRMK-JXOAFFINSA-N

SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O

CAS ??????: 1463-10-1(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	T+
?? ???? ??	26/27/28
?????	24/25
WGK ??	3
HS ??	29349990

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	1
0		0

5-Methyluridine C??? ??, ??, ??

??

5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.

??? ??

White Powder

??

A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.

5-Methyluridine ?? ?? ? ???

???

Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-5-methyl- (9CI) Uridine, 5-methyl-5'-O-(triphenylmethyl)- Uridine, 5-methyl-, 2',3',5'-triacetate Uridine, 5-methyl-, 2',3',5'-tribenzoate 2'-O-[2-[(??????)??]??]-5-??-??? beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate 1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE N3-Methyl-5-methyluridine BIS(O-TRIMETHYLSILYL)THYMINE ?? ??????? ?? ????

?? ??

THYMINE-BETA-D-ARABINOFURANOSIDE ????????? Stavudine

5-Methyluridine ?? ??

???( 488)?? ??

???	??	???	??	?? ?	??
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5-Methyluridine ?? ??:

??? 5-Methyluridine 2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine,2,2'-ANHYDRO-5-METHYLURIDINE,O2,2'-Anhydro-5-methyluridine 2'-DEOXY-2'-FLUORO-5-METHYLURIDINE DMT-2'O-Methyl-rU Phosphoramidite 2'-C-Methyluridine 2'-O-METHYL-5-METHYLURIDINE,5-METHY-5-METHYLURIDINE 2'-O-METHYLURIDINE,2''-O-METHYLURIDINE CRYSTALLINE 3-METHYLURIDINE THYMIDINE 5'-MONOPHOSPHATE, [2-14C] DISODIUM SALT (AA-UTP) SODIUM SALT 5-METHYL-[1'-13C]URIDINE HT MEDIA SUPPLEMENT AMINOALLYL UTP 5'-O-(DIMETHOXYTRITYL)-2'-O-METHYL-5-METHYLURIDINE FLUORESCEIN-12-UTP 5-formyloxymethyluridine THYMIDINE-3',5'-DIPHOSPHATE, DISODIUM SALT

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