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??????-11

??????-11
??????-11 ??? ???
?? ??:
161258-30-6
???:
??????-11
???(??):
??????-11
???:
Hexapeptide-11
???(??):
Hexapeptide-11;H-Phe-Val-Ala-Pro-Phe-Pro-OH;L-Proline, L-phenylalanyl-L-valyl-L-alanyl-L-prolyl-L-phenylalanyl-;(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid
CBNumber:
CB13134442
???:
C36H48N6O7
??? ??:
676.8
MOL ??:
161258-30-6.mol

??????-11 ??

?? ?
1035.1±65.0 °C(Predicted)
??
1.269±0.06 g/cm3(Predicted)
?? ?? (pKa)
3.43±0.20(Predicted)
??? ??
Solid
??
White to off-white
???
Phe-Val-Ala-Pro-Phe-Pro
InChIKey
GFEYWOGCSROPRT-OBXVVNIGSA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=CC=C1)N

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??????-11 C??? ??, ??, ??

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Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.

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Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin.

Physiological effects

Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities. In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity.

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