Omarigliptin (MK-3102)
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Omarigliptin (MK-3102) ??
- ?? ?
- 529.4±60.0 °C(Predicted)
- ??
- 1.61±0.1 g/cm3(Predicted)
- ?? ??
- 2-8°C(protect from light)
- ???
- insoluble in EtOH; insoluble in H2O; ≥17.15 mg/mL in DMSO
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 9.11±0.60(Predicted)
- ??
- White to off-white
- InChI
- InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
- InChIKey
- MKMPWKUAHLTIBJ-ISTRZQFTSA-N
- SMILES
- [C@H]1(C2=CC(F)=CC=C2F)OC[C@H](N2CC3=CN(S(C)(=O)=O)N=C3C2)C[C@@H]1N
- CAS ??????
- 1226781-44-7
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
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Omarigliptin (MK-3102) C??? ??, ??, ??
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Merck earned its first global approval for omarigliptin in Japan in 2015, and phase III development is ongoing in other countries around the globe for this interesting small molecule DPP-4 inhibitor. Interestingly, while most DPP-4 inhibitors used to treat type 2 DM require daily administration, omarigliptin is a weekly treatment. The process-scale synthesis of omarigliptin has been nicely described in an October 2015 paper from the Merck process group.??
Omarigliptin is a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as treatment for type 2 diabetes.Omarigliptin (MK-3102) ?? ?? ? ???
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Omarigliptin (MK-3102) ?? ??
???( 270)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
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| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
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| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
Omarigliptin (MK-3102) ?? ??:
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbaMate
MK-2206 2HCl
MK-4101
mk-1064
MK 0557
MK-5172
Mk-2461 .
(E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT
OLANZAPINE N-OXIDE
5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid
10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide
Olmesartan impurity 43
Olanzapine Related Compound B
Okasepine impurity 4
Olaparib Metabolite M12
Teneligliptin Hydrobromide
Saxagliptin
Alogliptin benzoate