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N,N'-??(????????)??-??(II)

N,N'-??(????????)??-??(II)
N,N'-??(????????)??-??(II) ??? ???
?? ??:
53177-12-1
???:
N,N'-??(????????)??-??(II)
???(??):
N,N'-??(????????)??-??(II)
???:
N,N'-bis(salicylideneamino)ethane-manganese(II)
???(??):
EUK-8;EUK-8 >=95% (HPLC);Manganese(salen) chloride;(Salen)manganese(III) chloride;(Salen)manganese(III) chloride (EUK-8);Manganese(salen) chloride, 10 mM in DMSO;N,N'-bis(salicylideneamino)ethane-manganese(II);Chloro(bis(salicylidene)ethylenediamine)manganese;Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese;N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
CBNumber:
CB11380553
???:
C16H14ClMnN2O2
??? ??:
356.685609
MOL ??:
53177-12-1.mol
MSDS ??:
SDS

N,N'-??(????????)??-??(II) ??

?? ??
-20°C
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H2O: ???1mg/mL, ??
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H2O: 1mg/mL, clear

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WGK ?? 3

N,N'-??(????????)??-??(II) C??? ??, ??, ??

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[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties.

Biochem/physiol Actions

EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

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N,N'-??(????????)??-??(II) ?? ??

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