ChemicalBook >?? ???? >?0016

?0016

?0016 ??? ???

?? ??:: 339068-25-6

???:: ?0016

???(??):: ?0016

???:: HET0016

???(??):: HET0016;HET0016,HET-0016;HET-0016, 20-HETE synthase inhibitor;N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine;N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine;N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE;N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide;N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide;N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE;Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-

CBNumber:: CB0149064

???:: C12H18N2O

??? ??:: 206.28

MOL ??:: 339068-25-6.mol

MSDS ??:: SDS

?? ?? 74

?0016 ??

???: 138-140°C

?? ??: Hygroscopic, -20°C Freezer, Under inert atmosphere

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CAS ??????: 339068-25-6

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H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

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P261	??·?·??·???·??·...·????? ??? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405	???? ?????.

?0016 C??? ??, ??, ??

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20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC₅₀ of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC₅₀s in the μM range. The IC₅₀ values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.

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20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.[Cayman Chemical]

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???	??	???	??	?? ?	??
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?0016 ?? ??:

1-Aminobenzotriazole Ketoconazole ROQUEFORTINE C METYRAPONE 3,3'-Diindolylmethane (S)-MEPHENYTOIN 8-Methoxypsoralen TROLEANDOMYCIN PROADIFEN HYDROCHLORIDE GLUCORAPHANIN 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE RESORUFIN ETHYL ETHER 4-Butyl-2-methylaniline N-(4-BUTYL-2-METHYLPHENYL)-N'-[(4-CHLORO-3-NITROBENZOYL)OXY]IMINOFORMAMIDE HET0016

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