カンナビジオール 化學(xué)特性,用途語,生産方法
定義
本品は、次の化學(xué)式で表される有機(jī)化合物である。
解説
カンナビジオール，大麻草に含まれるカンナビノイドの一種。鎮(zhèn)痛?抗痙攣(けいれん)?抗炎癥?食欲増進(jìn)?抗不安?免疫抑制などの薬理作用を有し、陶酔感や幻覚などは引き起こさないとされる。CBD（cannabidiol）?！匹去楗谣丧恁螗圣鹰惟`ル[補(bǔ)説]大麻草の成熟した莖や種子から抽出されるカンナビジオールは大麻取締法による規(guī)制の対象外となるため、國內(nèi)でもカンナビジオールを含む健康食品や化粧品が流通している。
化粧品の成分用途
抗アクネ剤、皮膚コンディショニング剤、皮膚保護(hù)剤、酸化防止剤、薬用収れん剤-皮膚防御剤
効能
抗けいれん薬, 抗てんかん薬, カンナビノイド受容體作動(dòng)薬
化學(xué)的特性
Off-White Solid
使用
Major non-psychoactive constituent of Cannabis. Exhibits multiple bioactivities including anticonvulsant, anxiolytic and anti-inflammatory effects. The (+)-isomers were more active than the (-)-isomers.
定義
ChEBI: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
生物活性
Non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo . GPR55 and weak CB 1 antagonist (IC 50 values are 0.445 and 3.35 μ M), CB 2 receptor inverse agonist and inhibitor of anandamide uptake (IC 50 = 27.5 μ M). Also a weak agonist at VR1 vanilloid receptors (EC 50 = 3.5 μ M).
薬理學(xué)
Cannabidiol, a constituent of the cannabis plant, has been receiving considerable attention of late for its potential therapeutic utility, including potential anxiolytic, anticonvulsant,anti-inflammatory, and neuroprotective effects. Cannabidiol has a complex pharmacology. In contrast to THC, cannabidiol has minimal affinity for CB1 and CB2 receptors and produces no intoxication. The effects of cannabidiol in combination with THC have been mixed, with some data suggesting it may reduce THC’s mood-altering and cognitive effects, while others show no effect. If oral cannabidiol reduces cannabis intoxication, it could be a potential medication to treat CUD. However, Haney et al. tested a range of cannabidiol doses (200–800 mg) in combination with active and placebo cannabis and found no cannabidiol effect on the subjective, reinforcing, or cardiovascular effects of smoked cannabis, providing little support for cannabidiol’s utility as a medication to reduce cannabis’ positive reinforcing and subjective effects.
カンナビジオール 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品