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ChemicalBook >> CAS DataBase List >>2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

CAS No.
950596-58-4
Chemical Name:
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Synonyms
Erlotinib Impurity 134;Erlotinib Hydrochloride iMpurity 23;2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile;Benzonitrile, 2-amino-4,5-bis(2-methoxyethoxy)-;2-((4-chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
CBNumber:
CB82470977
Molecular Formula:
C13H18N2O4
Molecular Weight:
266.29
MDL Number:
MFCD16619377
MOL File:
950596-58-4.mol
Last updated:2025-07-29 17:05:30

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Properties

Melting point 73-77 °C
Boiling point 445.5±45.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 1.85±0.10(Predicted)
color Pale Beige to Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A898405 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile 950596-58-4 100mg $45 2021-12-16 Buy
TRC A898405 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile 950596-58-4 500mg $60 2021-12-16 Buy
AK Scientific Z1739 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile 950596-58-4 5g $96 2021-12-16 Buy
Biosynth Carbosynth FA152677 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile 950596-58-4 5mg $117 2021-12-16 Buy
Biosynth Carbosynth FA152677 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile 950596-58-4 10mg $203 2021-12-16 Buy
Product number Packaging Price Buy
A898405 100mg $45 Buy
A898405 500mg $60 Buy
Z1739 5g $96 Buy
FA152677 5mg $117 Buy
FA152677 10mg $203 Buy

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Chemical Properties,Uses,Production

Uses

2-((4-Chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol is an impurity if Erlotinib (E625008) a EGFR-targeted drug in the treatment of non-small cell lung cancer.

Uses

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.

Synthesis

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

236750-65-5

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

950596-58-4

The general procedure for the synthesis of 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile from 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile is as follows: 1) Catalytic hydrogenation reaction: 200g of 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile obtained from the previous step was dissolved in 5L of anhydrous methanol, and 10g of Pd/C catalyst (with 10% Pd content) was added, and mixed with thorough stirring. H2 was used as the reducing agent, and the flow rate of the slurry pump was adjusted so that the flow rate of the reaction material was 40.0 g/min, and the gas flow meter controlled the flow rate of H2 to ensure that the molar ratio of nitro compounds to H2 was 1:3.5.The temperature of the reaction was 90 ℃, and the temperature of the cooling module was 25 ℃, and the residence time of the reaction was 25 s, and the pressure of the reaction was 1.5 MPa.After the completion of the reaction, the reaction liquid was collected from the outlet of the cooling module After the reaction is completed, the reaction liquid is collected from the outlet of the cooling module for post-treatment. 2) Post-treatment: Recover the Pd/C catalyst by filtration and recover the organic solvent by distillation under reduced pressure. Add 1.2L of acetone to the residue, stir to dissolve and then add 450mL of concentrated hydrochloric acid, stir to crystallize for 1 hour. The filter cake was collected by filtration, dissolved in 2L of water, and the pH was adjusted to 8.0 with 2 mol/L NaOH solution. 2L of ethyl acetate was used for extraction in two portions of 1L each, and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 160.83 g of 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile in 80.77% yield and 99.43% purity.

References

[1] Organic Process Research and Development, 2007, vol. 11, # 5, p. 813 - 816
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 3, p. 909 - 914
[3] Patent: CN108358798, 2018, A. Location in patent: Paragraph 0052; 0057; 0067; 0077; 0087; 0112-0119; 0123
[4] Patent: WO2007/138612, 2007, A2. Location in patent: Page/Page column 10-11
[5] Patent: WO2007/138613, 2007, A2. Location in patent: Page/Page column 10-11

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Preparation Products And Raw materials

Global( 142)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 7632 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 340 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Hebei shuoxi biotechnology co. LTD 		+8613081092107 CHINA 964 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58

View Lastest Price from 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMino-4,5-bis (2-Methoxyethoxy)benzonitrile pictures 2025-07-29 2-AMino-4,5-bis (2-Methoxyethoxy)benzonitrile
950596-58-4
 US $2.00-6.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-Amino-4,5-bis(2-methoxyeth-oxy)benzonitrile pictures 2024-11-26 2-Amino-4,5-bis(2-methoxyeth-oxy)benzonitrile
950596-58-4
 US $0.00-0.00 / kg 1kg 99%(HPLC) 2000kg/Year Nanjing Fred Technology Co., Ltd
2-AMino-4,5-bis (2-Methoxyethoxy)benzonitrile pictures 2021-03-17 2-AMino-4,5-bis (2-Methoxyethoxy)benzonitrile
950596-58-4
 US $50.00 / g 10g 99.8% 10tons Hebei shuoxi biotechnology co. LTD

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Spectrum

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Erlotinib Hydrochloride iMpurity 23 2-((4-chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol Benzonitrile, 2-amino-4,5-bis(2-methoxyethoxy)- Erlotinib Impurity 134 950596-58-4