午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->950596-58-4

950596-58-4

950596-58-4 Structure

950596-58-4 Structure
IdentificationBack Directory
[Name]

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
[CAS]

950596-58-4
[Synonyms]

Erlotinib Hydrochloride iMpurity 23
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Benzonitrile, 2-amino-4,5-bis(2-methoxyethoxy)-
2-((4-chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
[EINECS(EC#)]

1308068-626-2
[Molecular Formula]

C13H18N2O4
[MDL Number]

MFCD16619377
[MOL File]

950596-58-4.mol
[Molecular Weight]

266.29
Chemical PropertiesBack Directory
[Melting point ]

73-77 °C
[Boiling point ]

445.5±45.0 °C(Predicted)
[density ]

1.17±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

1.85±0.10(Predicted)
[color ]

Pale Beige to Beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
Hazard InformationBack Directory
[Uses]

2-((4-Chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol is an impurity if Erlotinib (E625008) a EGFR-targeted drug in the treatment of non-small cell lung cancer.
[Uses]

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.
[Synthesis]

4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile

236750-65-5

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

950596-58-4

The general procedure for the synthesis of 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile from 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile is as follows: 1) Catalytic hydrogenation reaction: 200g of 4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile obtained from the previous step was dissolved in 5L of anhydrous methanol, and 10g of Pd/C catalyst (with 10% Pd content) was added, and mixed with thorough stirring. H2 was used as the reducing agent, and the flow rate of the slurry pump was adjusted so that the flow rate of the reaction material was 40.0 g/min, and the gas flow meter controlled the flow rate of H2 to ensure that the molar ratio of nitro compounds to H2 was 1:3.5.The temperature of the reaction was 90 ℃, and the temperature of the cooling module was 25 ℃, and the residence time of the reaction was 25 s, and the pressure of the reaction was 1.5 MPa.After the completion of the reaction, the reaction liquid was collected from the outlet of the cooling module After the reaction is completed, the reaction liquid is collected from the outlet of the cooling module for post-treatment. 2) Post-treatment: Recover the Pd/C catalyst by filtration and recover the organic solvent by distillation under reduced pressure. Add 1.2L of acetone to the residue, stir to dissolve and then add 450mL of concentrated hydrochloric acid, stir to crystallize for 1 hour. The filter cake was collected by filtration, dissolved in 2L of water, and the pH was adjusted to 8.0 with 2 mol/L NaOH solution. 2L of ethyl acetate was used for extraction in two portions of 1L each, and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 160.83 g of 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile in 80.77% yield and 99.43% purity.

[References]

[1] Organic Process Research and Development, 2007, vol. 11, # 5, p. 813 - 816
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 3, p. 909 - 914
[3] Patent: CN108358798, 2018, A. Location in patent: Paragraph 0052; 0057; 0067; 0077; 0087; 0112-0119; 0123
[4] Patent: WO2007/138612, 2007, A2. Location in patent: Page/Page column 10-11
[5] Patent: WO2007/138613, 2007, A2. Location in patent: Page/Page column 10-11
Spectrum DetailBack Directory
[Spectrum Detail]

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile(950596-58-4)1HNMR
950596-58-4 suppliers list
Company Name: ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Tel: +86-13017695106 +86-13676922317 , +86-13676922317
Website:
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Website: http://www.cooperate-pharm.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Anqing Chico Pharmaceutical Co., Ltd.
Tel: 15380796838
Website: www.yuhua99.com/ShowSupplierProductsList30721/0_EN.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: NINGBO INNO PHARMCHEM CO., LTD.
Tel: 13867897135
Website: en.nbinno.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.yuhua99.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Hebei shuoxi biotechnology co. LTD
Tel: +8613081092107
Website: www.yuhua99.com/ShowSupplierProductsList1203517/0_EN.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: Jinan Honest Pharm Co., Ltd
Tel: +8615318812076 , +8615318812076
Website: www.jnhonestpharm.com/en/
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +86-0519-85551759 +8613506123987 , +8613506123987
Website: http://www.neostarunited.com
Company Name: SIMAGCHEM CORP
Tel: +86-5922680277 +86-13806087780 , +86-13806087780
Website: http://www.simagchem.com/
Company Name: Hebei Binshare New Material Co. Ltd
Tel: +8618633865755 , +8618633865755
Website: https://www.binsharematerial.com/
Company Name: Nanjing Fred Technology Co., Ltd.
Tel: +86-02584696168 15380713688 , 15380713688
Website: www.fredbio.com
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: www.yuhua99.com/ShowSupplierProductsList418627/0_EN.htm
Company Name: Hebei shenghao import and export trade co. LTD
Tel: +8618431136903 , +8618431136903
Website: www.yuhua99.com/ShowSupplierProductsList1507121/0_EN.htm
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Tags:950596-58-4 Related Product Information
183322-18-1 3943-89-3 299912-61-1 52670-38-9 183321-83-7 236750-62-2 1624294-38-7 183321-82-6 882172-60-3 183322-17-0 183321-85-9 236750-65-5 183321-74-6 183320-51-6 1839513-98-2 2204518-92-1 183321-86-0 183322-16-9

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.