EPLIVANSERIN FUMARATE
- CAS No.
- 130580-02-8
- Chemical Name:
- EPLIVANSERIN FUMARATE
- Synonyms
- SR 46349B;SR-46349 Fumarate;EPLIVANSERIN FUMARATE;SR-46349 hemifumarate;Eplivanserin hemifumarate;SR-46349 hemifumarate salt;Eplivanserin hemifumarate salt;SR-46349 hemifumarate salt >=98% (HPLC);TRANS-2''-FLUORO-4-HYDROXYCHALCONE O-[(Z)-2-(DIMETHYLAMINO)ETHYL]OXIME--FUMARIC ACID (2:1);4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt
- CBNumber:
- CB81011733
- Molecular Formula:
- C23H25FN2O6
- Molecular Weight:
- 444.46
- MDL Number:
- MFCD00893361
- MOL File:
- 130580-02-8.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to off-white |
| FDA UNII | BT8UYC46KA |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
EPLIVANSERIN FUMARATE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7201 | SR-46349 hemifumarate salt ≥98% (HPLC) | 130580-02-8 | 5mg | $103 | 2025-07-31 | Buy |
| Sigma-Aldrich | S7201 | SR-46349 hemifumarate salt ≥98% (HPLC) | 130580-02-8 | 25mg | $399 | 2025-07-31 | Buy |
| Tocris | 4958 | Eplivanserinhemifumarate ≥98%(HPLC) | 130580-02-8 | 10 | $164 | 2021-12-16 | Buy |
| Tocris | 4958 | Eplivanserinhemifumarate ≥98%(HPLC) | 130580-02-8 | 50 | $690 | 2021-12-16 | Buy |
| Usbiological | 255254 | Eplivanserin hemifumarate | 130580-02-8 | 10mg | $418 | 2021-12-16 | Buy |
EPLIVANSERIN FUMARATE Chemical Properties,Uses,Production
Uses
Eplivanserin Hemifumarate is a 5-HT2A antagonist.
Biological Activity
SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.1 It increases the signal transduction induced by 5-HT2 receptor by binding with high affinity.2 SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.3', 'ASTAR (Antagonist of Serotonin 5HT2A Receptors).
in vivo
Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2].
IC 50
5-HT2A Receptor: 5.8 nM (IC50); 5-HT2C Receptor: 120 nM (IC50)
storage
Store at +4°C
EPLIVANSERIN FUMARATE Preparation Products And Raw materials
Raw materials
Preparation Products
EPLIVANSERIN FUMARATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2123 | 70 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28787 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4172 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Tianjin Nuokang Pharmaceutical Technology Co., Ltd. | 022-23989838 13810451150 | 44766350@qq.com | China | 2171 | 58 |
View Lastest Price from EPLIVANSERIN FUMARATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Eplivanserin hemifumarate
130580-02-8
|
US $1190.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Eplivanserin hemifumarate
130580-02-8
- US $1190.00 / mg
- TargetMol Chemicals Inc.
