N-BOC-3-MESYLOXYPIPERIDINE
- CAS No.
- 129888-60-4
- Chemical Name:
- N-BOC-3-MESYLOXYPIPERIDINE
- Synonyms
- tert-Butyl 3-((methylsulfonyl);1-Boc-3-methanesulfonyloxy-piper;N-BOC-3-(Methylsulfonyloxy)piperidine;1-Boc-3-methanesulphonyloxypiperidine;3-((methylsulfonyl)oxy)piperidine-1-carboxylate;tert-Butyl 3-Methylsulfonyloxypiperidin-1-carboxylate;tert-Butyl 3-Methylsulfonyloxypiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine;tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate;3-methylsulfonyloxy-1-piperidinecarboxylic acid tert-butyl ester
- CBNumber:
- CB81011470
- Molecular Formula:
- C11H21NO5S
- Molecular Weight:
- 279.35
- MDL Number:
- MFCD07787193
- MOL File:
- 129888-60-4.mol
- MSDS File:
- SDS
| Boiling point | 407.2±34.0 °C(Predicted) |
|---|---|
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -3.34±0.40(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-6-9(8-12)17-18(4,14)15/h9H,5-8H2,1-4H3 |
| InChIKey | WLAZHMYDLUILKR-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCCC(OS(C)(=O)=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-BOC-3-MESYLOXYPIPERIDINE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B663285 | 1-Boc-3-Methanesulfonyloxy-piperidine | 129888-60-4 | 25mg | $45 | 2021-12-16 | Buy |
| Oakwood | 047924 | 1-Boc-3-methanesulfonyloxypiperidine | 129888-60-4 | 250mg | $22 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8H64-1-05 | tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate 98.0% | 129888-60-4 | 1g | $79 | 2021-12-16 | Buy |
| AK Scientific | V1777 | N-Boc-3-mesyloxypiperidine | 129888-60-4 | 5g | $237 | 2021-12-16 | Buy |
| Matrix Scientific | 068941 | tert-Butyl 3-methylsulfonyloxypiperidine-1-carboxylate >95% | 129888-60-4 | 1g | $189 | 2021-12-16 | Buy |
N-BOC-3-MESYLOXYPIPERIDINE Chemical Properties,Uses,Production
Synthesis
85275-45-2
124-63-0
129888-60-4
Step 1. To a stirred solution of tert-butyl 3-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol) and triethylamine (5.027 g, 6.924 mL, 49.68 mmol) in dichloromethane (50 mL) was slowly added methanesulfonyl chloride (3.130 g, 2.115 mL, 27.32 mmol) under the conditions of an ice bath at 0°C. The reaction mixture was gradually warmed to room temperature over 3 hours. Upon completion of the reaction, the reaction mixture was washed with water and 1 M hydrochloric acid, followed by drying with magnesium sulfate, filtration and concentration in vacuum to afford tert-butyl 3-((methanesulfonyl)oxy)piperidine-1-carboxylate as a yellow oil (7.9 g, quantitative yield, with a small amount of residual solvent).1H NMR (400.0 MHz, CDCl3) δ 1.49 (s, 9H), 1.60- 1.57 (m, 1H), 2.04-1.79 (m, 3H), 3.08 (s, 3H), 3.38-3.32 (m, 1H), 3.50-3.43 (m, 1H), 3.70-3.60 (m, 2H) and 4.74 (br s, 1H) ppm.
References
[1] Patent: US2013/115310, 2013, A1. Location in patent: Paragraph 0248; 0249
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0485; 0486
[3] Carbohydrate Research, 1990, vol. 204, # 1, p. 11 - 25
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[5] Patent: US2017/305920, 2017, A1. Location in patent: Paragraph 0151; 0152
N-BOC-3-MESYLOXYPIPERIDINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
