1-Cyano-1-cyclopropanecarboxylic acid
- CAS No.
- 6914-79-0
- Chemical Name:
- 1-Cyano-1-cyclopropanecarboxylic acid
- Synonyms
- 1-Cyanocyclopropane-1-carboxylic acid;1-CYANOCYCLOPROPANECARBOXYLIC ACID;TIMTEC-BB SBB006670;2-CYANO-2-CYCLOPROPYLACETIC ACID;1-CYANO-1-CYCLOPROPAN CARBOXYLICACID;1-Cyanocycllopropanecarboxylic Acid;1-CYANO-1-CYCLOPROPANECARBOXYLIC ACID;Cyclopropanecarboxylic acid, 1-cyano-;1-Cyano-1-cyclopropanecarboxylic acid 97%;1-CYANO-1-CYCLOPROPANECARBOXYLIC ACID, 9 7%
- CBNumber:
- CB7271520
- Molecular Formula:
- C5H5NO2
- Molecular Weight:
- 111.1
- MDL Number:
- MFCD00190651
- MOL File:
- 6914-79-0.mol
- MSDS File:
- SDS
| Melting point | 140 °C (lit.) |
|---|---|
| Boiling point | 142 °C |
| Density | 1.3113 (rough estimate) |
| refractive index | 1.4260 (estimate) |
| storage temp. | 2-8°C |
| pka | 2.31±0.20(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 6914-79-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 20/21/22-34 | |||||||||
| Safety Statements | 26-27-36/37/39-45-25 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| NFPA 704 |
|
1-Cyano-1-cyclopropanecarboxylic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 343390 | 1-Cyano-1-cyclopropanecarboxylic acid 97% | 6914-79-0 | 5g | $56 | 2025-07-31 | Buy |
| TCI Chemical | C3490 | 1-Cyanocyclopropanecarboxylic Acid min. 95.0 % | 6914-79-0 | 1G | $57 | 2025-07-31 | Buy |
| TCI Chemical | C3490 | 1-Cyanocyclopropanecarboxylic Acid min. 95.0 % | 6914-79-0 | 5G | $170 | 2025-07-31 | Buy |
| Usbiological | 409547 | 1-Cyano-1-cyclopropanecarboxylic acid | 6914-79-0 | 100mg | $305 | 2021-12-16 | Buy |
| TRC | C962603 | 1-Cyano-1-cyclopropanecarboxylic acid | 6914-79-0 | 500mg | $65 | 2021-12-16 | Buy |
1-Cyano-1-cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to light brown crystalline powder
Uses
1-Cyano-1-cyclopropanecarboxylic acid may be used in the synthesis of amidine-based nanomolar sphingosine kinase1 subtype-selective inhibitors.
Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 2969, 1975 DOI: 10.1021/jo00908a030
General Description
1-Cyano-1-cyclopropanecarboxylic acid (1-Cyanocyclopropanecarboxylic acid) is a substituted cyclopropane. It is the intermediate formed during homoconjugate addition of nucleophiles to cyclopropane-1,1-dicarboxylate derivative.
Synthesis
6914-73-4
6914-79-0
General procedure for the synthesis of 1-cyano-1-cyclopropanecarboxylic acid from methyl 1-cyanocyclopropanecarboxylate: KOH (13.78 g, 85%, 209 mmol) was dissolved in 80 mL of ethanol, and then this solution was added to a 100 mL ethanol solution of methyl 1-cyano-1-cyclopropanecarboxylate (25.64 g, 205 mmol), and the reaction was stirred for 1 hour. After completion of the reaction, the mixture was evaporated and concentrated, dissolved in 200 mL of water and the aqueous phase was washed with 30 mL of chloroform. Subsequently, the aqueous phase was acidified with hydrochloric acid to pH=1. 30 g of NaCl was added to the acidified mixture, followed by 6 extractions with 50 mL of chloroform. All organic layers were combined, dried with anhydrous MgSO4 and finally the solvent was evaporated under vacuum to afford the target product 1-cyano-1-cyclopropanecarboxylic acid (20.60 g, 90% yield). The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 1.73 (m, 4H), 11.08 (s, 1H).
References
[1] Tetrahedron, 2013, vol. 69, # 16, p. 3495 - 3505
1-Cyano-1-cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Cyano-1-cyclopropanecarboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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View Lastest Price from 1-Cyano-1-cyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-03-11 | 1-Cyano-1-cyclopropanecarboxylic acid
6914-79-0
|
US $6.86 / KG | 1KG | 95.0%-99.0% | 1kg-100kg | Career Henan Chemical Co |
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- 1-Cyano-1-cyclopropanecarboxylic acid
6914-79-0
- US $6.86 / KG
- 95.0%-99.0%
- Career Henan Chemical Co
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