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ChemicalBook >> CAS DataBase List >>1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE

CAS No.
353791-85-2
Chemical Name:
1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE
Synonyms
J 113863;J-113863, 10 mM in DMSO;1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE;CCR,Inhibitor,inhibit,rheumatoid,J-113863,CCR1,CCR3,CC chemokine receptor,Chemotaxis,collagen,arthritis,J 113863,J113863,CD18,anti-inflammatory
CBNumber:
CB72453425
Molecular Formula:
C30H37Cl2IN2O2
Molecular Weight:
655.44
MDL Number:
MFCD09971097
MOL File:
353791-85-2.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE Properties

storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
form Powder
color Light yellow to yellow
FDA UNII E32U2ESR7J

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 2595 J113863 ≥98%(HPLC) 353791-85-2 1 $108 2021-12-16 Buy
Tocris 2595 J113863 ≥98%(HPLC) 353791-85-2 10 $233 2021-12-16 Buy
Tocris 2595 J113863 ≥98%(HPLC) 353791-85-2 50 $980 2021-12-16 Buy
TRC U130608 UCB35625 353791-85-2 5mg $835 2021-12-16 Buy
TRC U130608 UCB35625 353791-85-2 10mg $1470 2021-12-16 Buy
Product number Packaging Price Buy
2595 1 $108 Buy
2595 10 $233 Buy
2595 50 $980 Buy
U130608 5mg $835 Buy
U130608 10mg $1470 Buy

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE Chemical Properties,Uses,Production

Uses

UCB 35625 is an antagonist of CCR1, which are receptors prevalent in chronic inflammatory processes. UCB 35625 displays antiarthritic activity and is also a selective antagonist of CCR3.

Biological Activity

Potent chemokine receptor 1 (CCR1) antagonist (IC 50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC 50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. Isomer of UCB 35625 (1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidiniumiodide ).

in vivo

J-113863 (3-10 mg/kg; intraperitoneal injection; once daily; for 11 days; DBA-1 male mice) treatment improves paw inflammation and joint damage, and dramatically decreases cell infiltration into joints in arthritic mice[2].

Animal Model:DBA-1 male mice (10-12 weeks) induced with Collagen[2]
Dosage:3 mg/kg, 10 mg/kg
Administration:Intraperitoneal injection; once daily; for 11 days
Result:Improved paw inflammation and joint damage, and dramatically decreased cell infiltration into joints.

IC 50

CCR1: 0.9 nM (IC50, Human CCR1); CCR1: 5.8 nM (IC50, Mouse CCR1); CCR3: 0.58 nM (IC50, Human CCR3); CCR3: 460 nM (IC50, Mouse CCR3)

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE Suppliers

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6708 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29770 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 25005 58

353791-85-2(1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE)Related Search:

1,4-CIS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE J 113863 CCR,Inhibitor,inhibit,rheumatoid,J-113863,CCR1,CCR3,CC chemokine receptor,Chemotaxis,collagen,arthritis,J 113863,J113863,CD18,anti-inflammatory J-113863, 10 mM in DMSO 353791-85-2 C30H37Cl2N2O2I