1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
- CAS No.
- 876317-19-0
- Chemical Name:
- 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
- Synonyms
- N-Boc-4-oxo-DL-Proline;BOC- 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;1-Boc-4-oxo-2-pyrrolidinecarboxylic acid;N-BOC-4-oxopyrrolidine-2-carboxylic acid;4-OXOPYRROLIDINE-2-CARBOXYLIC ACID, N-BOC PROTECTED;4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid;1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid 95%
- CBNumber:
- CB7103726
- Molecular Formula:
- C10H15NO5
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD02668169
- MOL File:
- 876317-19-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB139726 | 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 876317-19-0 | 100mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB139726 | 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 876317-19-0 | 250mg | $100 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H58-1-JF | 1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid | 876317-19-0 | 1g | $152 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB139726 | 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 876317-19-0 | 500mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB139726 | 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | 876317-19-0 | 1g | $250 | 2021-12-16 | Buy |
1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
1-[(tert-Butoxy)carbonyl]-4-oxopyrrolidine-2-carboxylic Acid may be useful in the preparation of pyridinylethynyldihydropyrroloquinazolinone derivatives and analogs for use as metabotropic glutamate receptor 5 modulators.
Synthesis
40350-82-1
876317-19-0
General procedure for the synthesis of 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid from 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid: 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (178 g, 0.77 mol) was dissolved in dichloromethane (2.0 L), trichloroisocyanuric acid (178.89 g, 0.77 mol), followed by 2,2,6,6-tetramethylpiperidine oxide (6.05 g, 0.0385 mol). The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction was quenched with water and the insoluble material was removed by filtration. The aqueous phase was extracted several times with dichloromethane, all organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated to dryness under vacuum to give 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid (180 g) in 100% yield.
References
[1] Patent: CN105503891, 2016, A. Location in patent: Paragraph 0008; 0016
1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14459 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
876317-19-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-12-24 | 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
876317-19-0
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
876317-19-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
876317-19-0
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
