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ChemicalBook >> CAS DataBase List >>5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE

CAS No.
51516-70-2
Chemical Name:
5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
Synonyms
AKOS B029474;BUTTPARK 51\09-64;TIMTEC-BB SBB000407;5-Amino-1-(4-fluorophenyl);5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97%;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97%;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-fluorophenyl)-
CBNumber:
CB6663838
Molecular Formula:
C10H7FN4
Molecular Weight:
202.19
MDL Number:
MFCD00102729
MOL File:
51516-70-2.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:54

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Properties

Melting point 164-165°C
Boiling point 394.1±37.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka -0.92±0.10(Predicted)
form solid
Appearance Yellow to brown Solid
CAS DataBase Reference 51516-70-2(CAS DataBase Reference)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05, GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  20/21/22-41
Safety Statements  22-36/37/39-39-26
RIDADR  3439
WGK Germany  3
Hazard Note  Irritant
HS Code  2933199090

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich JRD0041 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile Aldrich 51516-70-2 1g $107 2025-07-31 Buy
TRC A602185 5-Amino-1-(4-fluorophenyl)pyrazole-4-carbonitrile 51516-70-2 500mg $110 2021-12-16 Buy
Biosynth Carbosynth FA54002 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole 51516-70-2 250mg $65 2021-12-16 Buy
Biosynth Carbosynth FA54002 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole 51516-70-2 500mg $100 2021-12-16 Buy
Biosynth Carbosynth FA54002 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole 51516-70-2 1g $160 2021-12-16 Buy
Product number Packaging Price Buy
JRD0041 1g $107 Buy
A602185 500mg $110 Buy
FA54002 250mg $65 Buy
FA54002 500mg $100 Buy
FA54002 1g $160 Buy

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Uses,Production

Uses

5-Amino-1-(4-fluorophenyl)pyrazole-4-carbonitrile was used in the preparation of compounds that were shown to have anti-viral activity against TMV.

Synthesis

4-FLUOROPHENYLHYDRAZINE

371-14-2

Ethoxymethylenemalononitrile

123-06-8

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE

51516-70-2

GENERAL METHOD: (4-Fluorophenyl)hydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitate was collected by filtration and washed with cold water to afford 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile (10a) in 61% yield. The product characterization data were as follows: melting point: 173-174 °C. IR (cm^-1): 3297-3183 (NH2); 2225 (CN); 1662; 1568. ^1H NMR (400 MHz, DMSO-d6, TMS, δ in ppm): 7.31-7.25 (m, 2H, H3', H5'); 7.54- 7.49 (m, 2H, H2', H6'); 7.67 (s, 1H, H3). ^13C NMR (100 MHz, DMSO-d6, TMS, δ in ppm): 73.2 (C4); 114.8 (CN); 116.3 (d, J = 22.8 Hz, C3', C5'); 126.9 (d, J = 8.9 Hz, C2', C6'); 133.7 (d, J = 2.8 Hz, C1'); 141.7 (C5); 151.4 (C3); 161.2 (d, J = 243.6 Hz, C4'). ^19F NMR (376 MHz, DMSO-d6, TMS, δ in ppm): -114.26. EI-MS [M + 1]^+: 203.07.

References

[1] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[2] Tetrahedron Letters, 2008, vol. 49, # 2, p. 305 - 310
[3] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2892 - 2898
[5] Organic and Biomolecular Chemistry, 2007, vol. 5, # 17, p. 2758 - 2761

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials

Global( 61)Suppliers
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Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29733 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49730 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Allfluoro pharmaceutical co. ltd. 		+86-400-0216110 +86-15958047586 sales@allfluoro.com China 11385 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 021-021-61259108 18621169085 market03@meryer.com China 40228 62
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 sales@capotchem.com China 18207 66
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Spectrum

TIMTEC-BB SBB000407 BUTTPARK 51\09-64 AKOS B029474 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE 5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97% 5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97% 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 97% 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile97% 5-Amino-1-(4-fluorophenyl) 5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-fluorophenyl)- 51516-70-2 C10H7FN4