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ChemicalBook >> CAS DataBase List >>PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2

CAS No.
54784-44-0
Chemical Name:
PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
Synonyms
wy-18,185;LHRH, Phe(2)-Ala(6)-;[D-PHE2, D-ALA6]-LH-RH;[D-PHE2, D-ALA6]-LH-RH (HUMAN);(d-phe(sup2))-(d-ala(sup6))-lhrh;D-PHE2 D-ALA6-LUTEINIZING HORMONE &;GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2;PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2;PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2;D-phe2,D-ala6-luteinizing hormone*releasing hormo
CBNumber:
CB6337481
Molecular Formula:
C59H79N15O13
Molecular Weight:
1206.35
MDL Number:
MFCD00079994
MOL File:
54784-44-0.mol
Last updated:2025-04-18 09:52:29

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Properties

storage temp. −20°C
FDA UNII 0CH971OO9V

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
Hazard Codes  T
Risk Statements  60
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  OK6600000

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation PEP0005623 PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 95.00% 54784-44-0 5MG $497.77 2021-12-16 Buy
Product number Packaging Price Buy
PEP0005623 5MG $497.77 Buy

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Chemical Properties,Uses,Production

Uses

[D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities[1].

in vivo

[D-Phe2,D-Ala6]-LH-RH inhibits the LH and FSH release induced by LH-RH in immature male rats[1].
[D-Phe2,D-Ala6]-LH-RH (1 mg/rat, SC) shows marked antiovulatory and contraceptive activity[2]. [D-Phe2,D-Ala6]-LH-RH (0.625, 1.25, 2.5 mg/kg; s.c.; single dose; sacrificed 30 minutes) results a dose-dependent increase in stalk-median eminence (SME)-LHRH activity and decreases plasma LHRH activity as well in rats with hypophysectomized (hypox) at 25 days old[3].
[D-Phe2,D-Ala6]-LH-RH (25 mg/kg; s.c.; single dsoe) is effective in blocking the ovulation normally induced by LRH alone[4].

Animal Model:Adult female Sprague-Dawley rats (200-250 g)[2]
Dosage:1 mg/rat
Administration:SC injections, from 12:00 to 14:30 hr on the day of proestrus
Result:Showed marked antiovulatory and contraceptive activity, with 96% inhibition of ovulation.

References

[1] Vilchez-Martinez JA, et al. Comparison of the anti-LH/FSH-RH and anti-ovulatory activities of (D-Phe2, D-Leu6)-LH-RH and (D-Phe2, D-Ala6)-LH-RH. Endocr Res Commun. 1976;3(3-4):231-41. DOI:10.3109/07435807609056903
[2] Beattie CW, et al. Luteinizing hormone-releasing hormone. Antiovulatory activity of analogs substituted in positions 2 and 6. J Med Chem. 1975 Dec;18(12):1247-50. DOI:10.1021/jm00246a016
[3] Corbin A, et al. Effect of luteinizing hormone releasing hormone (LHRH) and an LHRH antagonist of hypothalamic and plasma LHRH of hypophysectomized rats. Endocrinology. 1976 Jan;98(1):247-50. DOI:10.1210/endo-98-1-247
[4] Corbin A, et al. Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2(1):1-23. DOI:10.3109/07435807509053836

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632 sales@reading-chemicals.com China 15178 58
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9980 55
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 Eric@peptidego.com China 7222 58
Wuxi Helen Biotechnology Co., Ltd., 0510-85629785 18013409632 sales@reading-chemicals.com China 14081 58
TCI (Shanghai) Chemical Trading Co., Ltd. 021-61109150 sales@tcisct.com China 29668 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 6791 58
Shanghai Toyang Biotechnology Co., LTD 021-59555769 13524932310 1405894150@qq.com China 7982 58
Nanjing Typeptide Biotechnology Co.,Ltd. 19941518170 sales@typeptide.com China 3721 58
Hangzhou ALLPEPTIDE Biotechnology Co., Ltd. 17342063383 sales@allpeptide.com China 5320 58

54784-44-0(PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2)Related Search:

(d-phe(sup2))-(d-ala(sup6))-lhrh (d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormon (d-phe(sup2))-(d-ala(sup6))-luteinizinghormone-releasinghormone 2-d-phenylalanine-6-d-alanine-luteinizinghormone-releasinghormone(pig wy-18,185 D-phe2,D-ala6-luteinizing hormone*releasing hormo D-PHE2 D-ALA6-LUTEINIZING HORMONE & LHRH, Phe(2)-Ala(6)- GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2 [D-PHE2, D-ALA6]-LH-RH [D-PHE2, D-ALA6]-LH-RH (HUMAN) [DPHE2,DALA6] LUTEINIZING HORMONE-RELEASING HORMONE [D-PHE2, D-ALA6]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN) PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 [D-Phe2,D-Ala6]lutenizing hormone-releasing factor 5-Oxo-L-Pro-D-Phe-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-Gly-NH2 GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2: GLP-DF-WSY-DA-LRPG-NH2 Glycinamide, 5-oxo-L-prolyl-D-phenylalanyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl-L-prolyl- 54784-44-0 C59H79N15O13 BioChemical Amino Acids and Peptides Biochemicals and Reagents LH-RH Peptides Releasing Factors