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ChemicalBook >> CAS DataBase List >>Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-

Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-

CAS No.
3033846-20-4
Chemical Name:
Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-
Synonyms
SIK-IN-2;Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]-
CBNumber:
CB614214895
Molecular Formula:
C22H22N6OS
Molecular Weight:
418.52
MDL Number:
MOL File:
3033846-20-4.mol
Last updated:2025-04-17 18:22:24

Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- Properties

Density 1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 9.52±0.20(predicted)

Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- Chemical Properties,Uses,Production

Uses

SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1].

References

[1] Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.

Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20701 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- SIK-IN-2 3033846-20-4