| Identification | Back Directory | [Name]
Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- | [CAS]
3033846-20-4 | [Synonyms]
Imidazo[1,2-a]pyridine-5-carbonitrile, 6-amino-3-[3-[(1-aminocyclopentyl)methoxy]-4-cyano-5-(methylthio)phenyl]- | [Molecular Formula]
C22H22N6OS | [MOL File]
3033846-20-4.mol | [Molecular Weight]
418.52 |
| Hazard Information | Back Directory | [Uses]
SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1]. | [References]
[1] Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1. |
|
|