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ChemicalBook >> CAS DataBase List >>PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

CAS No.
474711-89-2
Chemical Name:
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
Synonyms
BUTTPARK 85\04-05;Piperazine-1-carboxylic acid amid;1-piperazinecarboxamide hydrochloride;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL;Piperazine-1-carboxamide hydrochloride;PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL ISO 9001：2015 REACH
CBNumber:
CB3240920
Molecular Formula:
C5H12ClN3O
Molecular Weight:
165.62
MDL Number:
MFCD06408948
MOL File:
474711-89-2.mol
Last updated:2025-07-24 18:13:50

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Properties

Melting point 221-224°C
storage temp. Inert atmosphere,Room Temperature
Appearance White to off-white Solid
InChI InChI=1S/C5H11N3O.ClH/c6-5(9)8-3-1-7-2-4-8;/h7H,1-4H2,(H2,6,9);1H
InChIKey UVYKKFKLOUEFAR-UHFFFAOYSA-N
SMILES C(N1CCNCC1)(=O)N.Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H319-H335-H315-H332
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
HazardClass  IRRITANT
HS Code  2933399990

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B448905 Piperazine-1-carboxamideHydrochloride 474711-89-2 500mg $130 2021-12-16 Buy
TRC B448905 Piperazine-1-carboxamideHydrochloride 474711-89-2 50mg $45 2021-12-16 Buy
SynQuest Laboratories 4H53-5-03 Piperazine-1-carboxamide hydrochloride 98.0% 474711-89-2 250mg $50 2021-12-16 Buy
SynQuest Laboratories 4H53-5-03 Piperazine-1-carboxamide hydrochloride 98.0% 474711-89-2 5G $467 2021-12-16 Buy
AK Scientific 4107AE Piperazine-1-carboxylicacidamidehydrochloride 474711-89-2 10g $764 2021-12-16 Buy
Product number Packaging Price Buy
B448905 500mg $130 Buy
B448905 50mg $45 Buy
4H53-5-03 250mg $50 Buy
4H53-5-03 5G $467 Buy
4107AE 10g $764 Buy

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Chemical Properties,Uses,Production

Uses

Piperazine-1-carboxamide Hydrochloride is used in preparation of heteroaromatic derivatives as PDE4 inhibitors.

Synthesis

tert-butyl 4-carbamoylpiperazine-1-carboxylate

883554-88-9

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

474711-89-2

General procedure for the synthesis of piperazine-1-amide hydrochloride from tert-butyl 4-carbamoylpiperazine-1-carboxylate: To a dichloromethane (DCM, 2 mL) solution of tert-butyl 4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) was added an ethyl acetate (EtOAc) solution of hydrochloric acid (4 M, 2 mL). The reaction mixture was stirred at room temperature for 30 min and then concentrated under reduced pressure to give piperazine-1-amide hydrochloride as a white solid (0.16 g, 100% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 3.71-3.73 (m, 4H), 3.25-3.27 (m, 4H); MS-ESI: m/z 130.10 [M + H - HCl]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00403
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1050; 1054-1056
[3] Patent: EP1593679, 2005, A1. Location in patent: Page/Page column 59

883554-88-9
474711-89-2
Synthesis of PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL from tert-butyl 4-carbamoylpiperazine-1-carboxylate

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Preparation Products And Raw materials

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5661 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22058 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11598 64

View Lastest Price from PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL pictures 2022-03-04 PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
474711-89-2
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL pictures 2019-12-20 PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
474711-89-2
 US $1.00 / KG 1KG 99% KG/T Career Henan Chemical Co

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Spectrum

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE BUTTPARK 85\04-05 PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL Piperazine-1-carboxamide hydrochloride 1-piperazinecarboxamide hydrochloride PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL ISO 9001：2015 REACH Piperazine-1-carboxylic acid amid 474711-89-2 C5H11N3OHCl C5H12ClN3O piperazines