U-46619 Glycine methyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
U-46619 is a stable analog of the endoperoxide PGH
2, and a TP receptor agonist. It exhibits properties similar to TXA
2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle. Mean EC
50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation, are 82, 145, and 65 nM, respectively. U-46619 glycine methyl ester contains a modification at the C-1 position of U-46619 that may uniquely alter its binding properties to the TP receptor or any of the PGH
2-
metabolizing enzymes. As a stable PGH
2 analog, it could therefore be a useful tool to explore the inhibition of various enzymes in the arachidonic acid metabolic pathway. U-46619 glycine methyl ester may also serve as a lipophilic prodrug form of U-46619 that will alter its distribution and pharmacokinetic properties. There are no published reports on the biological activity of U-46619 glycine methyl ester.
U-46619 Glycine methyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
